| Frequency of inclusion of patients with cardiogenic shock in trials of thrombolytic therapy. | |
| | |
MedLine Citation:
|
PMID: 8296736 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The purpose of this study was to determine the extent to which patients with cardiogenic shock have participated in trials of thrombolytic therapy, to examine factors associated with their exclusion from these trials, and to summarize data on the efficacy of thrombolysis in these patients. Previous publications were searched for all randomized, controlled studies involving the use of thrombolytic medications used in the treatment of acute myocardial infarction. Data were abstracted for year of trial publication, performance location, sample size, maximal allowable delay between symptom onset and treatment, and exclusion criteria. Of the 94 trials included in the analysis, 22% included patients with cardiogenic shock, 37% excluded them, and the remainder contained no information on their inclusion or exclusion. Only 2 trials provided data on the efficacy of thrombolytic therapy in patients with cardiogenic shock. Multivariate analysis revealed that studies conducted exclusively in the U.S. were significantly more likely to exclude patients in cardiogenic shock than those conducted outside of the U.S., as were studies that excluded patients with a previous myocardial infarction, studies published more recently, and smaller trials. Patients with cardiogenic shock have frequently been excluded from clinical trials of thrombolytic agents. As a result, data on the efficacy of thrombolytic agents in these patients is extremely limited. |
| | |
Authors:
|
N F Col; J H Gurwitz; J S Alpert; R J Goldberg |
Related Documents
:
|
3429486 - Burned-and-battered adults. 9129206 - Neutrophils from burn patients are unable to increase the expression of cd11b/cd18 in r... 762716 - The role of nadh-nadph oxidase activity in the leukocyte function of burned patients. 2648426 - Longitudinal assessment of breast development in adolescent female patients with burns ... 19440066 - Carbohydrate antigen-125: additional accuracy in identifying patients at risk of acute ... 1578966 - Anemia of renal failure. use of erythropoietin. |
Publication Detail:
|
Type: Journal Article; Meta-Analysis |
Journal Detail:
|
Title: The American journal of cardiology Volume: 73 ISSN: 0002-9149 ISO Abbreviation: Am. J. Cardiol. Publication Date: 1994 Jan |
Date Detail:
|
Created Date: 1994-02-25 Completed Date: 1994-02-25 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0207277 Medline TA: Am J Cardiol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 149-57 Citation Subset: AIM; IM |
Affiliation:
|
Department of Medicine, University of Massachusetts Medical School, Worcester 01655. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Humans Multivariate Analysis Myocardial Infarction / complications, drug therapy* Randomized Controlled Trials as Topic / statistics & numerical data* Shock, Cardiogenic / drug therapy*, etiology Thrombolytic Therapy / statistics & numerical data* Treatment Outcome |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Significance of anterior ST depression in inferior wall acute myocardial infarction.
Next Document: Long-term prognosis of medically treated patients with acute myocardial infarction and one-vessel co...