Document Detail

Frequency of hypothyroidism in patients of beta-thalassaemia.
MedLine Citation:
PMID:  20055273     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine the frequency of hypothyroidism in patients suffering from homozygous beta-thalassaemia. METHODS: This descriptive study included 70 diagnosed thalassaemia major patients aged 5-14 years. Demographic data as well as history of blood transfusion and chelation therapy was collected. Random blood samples were drawn and thyroid profile (serum thyroxine [T4], triiodothyronine [T3] and thyroid stimulating hormone concentrations [TSH]) was done by enzyme-linked immunosorbent assay (ELISA). Primary hypothyroidism was defined by a TSH level > 4 microIU/ml. Results were analysed by descriptive statistical methods. RESULTS: Primary hypothyroidism was seen in 18 (25.7%) patients. Of these, 17 had normal T4 levels with elevated TSH levels consistent with a diagnosis of compensated primary hypothyroidism whereas only one patient showed a decreased T4 level with elevated TSH (uncompensated primary hypothyroidism). Mean age of hypothyroid patients was 9.2 +/- 2.6 years. Frequency of hypothyroidism was associated with increased serum ferritin levels.CONCLUSION: Primary hypothyroidism occurs in a significant proportion of thalassaemia major patients in the absence of obvious clinical signs of hypothyroidism. Regular follow-up for early detection and timely treatment of such complications could improve the quality of life of these patients.
Sara Ahmed Malik; Serajuddaula Syed; Nisar Ahmed
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  JPMA. The Journal of the Pakistan Medical Association     Volume:  60     ISSN:  0030-9982     ISO Abbreviation:  J Pak Med Assoc     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-01-08     Completed Date:  2010-02-26     Revised Date:  2010-03-08    
Medline Journal Info:
Nlm Unique ID:  7501162     Medline TA:  J Pak Med Assoc     Country:  Pakistan    
Other Details:
Languages:  eng     Pagination:  17-20     Citation Subset:  IM    
Department of Pathology, Ziauddin University, Shahrah-e-Ghalib, Clifton, Karachi, Pakistan.
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MeSH Terms
Chi-Square Distribution
Child, Preschool
Enzyme-Linked Immunosorbent Assay
Hypothyroidism / blood,  epidemiology*
Pakistan / epidemiology
beta-Thalassemia / blood,  epidemiology*
Comment In:
J Pak Med Assoc. 2010 Feb;60(2):159; author reply 160

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