Document Detail

Frequency and hemostatic abnormalities in pre-DIC patients.
MedLine Citation:
PMID:  20452653     Owner:  NLM     Status:  MEDLINE    
Disseminated intravascular coagulation (DIC) sometimes has a poor outcome, and therefore early diagnosis and treatment are required. This study prospectively evaluated the hemostatic abnormalities and the onset of DIC in 613 patients with underlying diseases to identify a useful marker for diagnosing Pre-DIC. Pre-DIC was defined as the condition of patients within a week before the onset of DIC. Initially, 34.4% of patients were diagnosed with DIC, and about 8.5% of the patients without DIC were diagnosed as DIC within a week after registration (pre-DIC). The mortality of DIC, Pre-DIC and "without DIC" was 35.3%, 32.4% and 17.2%, respectively. All hemostatic parameters were significantly worse in "DIC" than "without DIC" and the values of the prothrombin time ratio, platelet count and fibrin monomer complex could classify the three groups; "DIC", "pre-DIC" and "without DIC". No useful marker was identified that provided an adequate cutoff value to differentiate "pre-DIC" from "without DIC". A multivariate analysis identified clinical symptoms that were related to poor outcome. DIC must be treated immediately; there is no specific marker to identify pre-DIC.
Kohji Okamoto; Hideo Wada; Tsuyoshi Hatada; Toshimasa Uchiyama; Kazuo Kawasugi; Toshihiko Mayumi; Satoshi Gando; Shigeki Kushimoto; Yoshinobu Seki; Seiji Madoiwa; Hidesaku Asakura; Shin Koga; Toshiaki Iba; Ikuro Maruyama;
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-05-10
Journal Detail:
Title:  Thrombosis research     Volume:  126     ISSN:  1879-2472     ISO Abbreviation:  Thromb. Res.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-06-14     Completed Date:  2010-09-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0326377     Medline TA:  Thromb Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  74-8     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2010 Elsevier Ltd. All rights reserved.
First Department of Surgery, University of Occupational and Environmental Health School of Medicine, KitaKyushu, Japan.
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MeSH Terms
Aged, 80 and over
Biological Markers / blood
Disseminated Intravascular Coagulation / blood*,  diagnosis*
Fibrin Fibrinogen Degradation Products
Hemostasis / physiology*
Hemostatics / diagnostic use
Middle Aged
Multicenter Studies as Topic
Platelet Count
Prospective Studies
Reg. No./Substance:
0/Biological Markers; 0/Fibrin Fibrinogen Degradation Products; 0/Hemostatics; 0/fibrinmonomer

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