Document Detail

Frequency of gastroesophageal reflux in patients with liver cirrhosis.
MedLine Citation:
PMID:  8270239     Owner:  NLM     Status:  MEDLINE    
Twenty-five adult patients with liver cirrhosis, and another 30 patients with no liver disease but referred with symptoms suggestive of gastroesophageal reflux disease were selected at random. Twenty-four hour ambulatory intra-esophageal pH measurement and upper gastrointestinal endoscopy were carried out on all patients recruited. Applying the former test, 16 (64%) of the patients with liver cirrhosis have gastroesophageal reflux disease. This figure is comparable with the 70% (21/30) rate recorded in the group of dyspeptic patients clinically thought to have the disorder. A positive endoscopic diagnosis was much lower at 12% and 23%, respectively. No significant differences were observed among liver disease patients when they were subdivided in accordance with the etiology of liver cirrhosis and the grade of esophageal varices. We conclude that gastroesophageal reflux disease occurs at a high frequency (64%) in patients with liver cirrhosis and portal hypertension, irrespective of the etiology of cirrhosis and the grade of esophageal varices. It is therefore considered to be the main cause of esophagitis in these patients, and that it might play a role in initiating a variceal bleeding episode. The latter hypothesis needs further evaluation.
A M Ahmed; M A al Karawi; S Shariq; A E Mohamed
Related Documents :
20832949 - Endotoxaemia in the pathogenesis of cytopenias in liver cirrhosis. could oral antibioti...
20810049 - Effect of carvedilol on portal pressure estimated by hepatic vein doppler ultrasound wa...
6108449 - Aminoacid therapy of alcoholic hepatitis.
1397889 - Mobilization of malignant ascites with diuretics is dependent on ascitic fluid characte...
12544699 - Gross chylous ascites in cirrhosis with massive portal vein thrombosis: diagnostic valu...
21471799 - Prospective randomized comparison of oral sodium phosphate and sennoside a+b calcium la...
12122519 - Kinetic and reversibility of mechanical ventilation-associated pulmonary and systemic i...
16127179 - Large-scale cohort study on the relationship between serum lipid concentrations and ris...
22929639 - Histopathologic study of chronic antral gastritis.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hepato-gastroenterology     Volume:  40     ISSN:  0172-6390     ISO Abbreviation:  Hepatogastroenterology     Publication Date:  1993 Oct 
Date Detail:
Created Date:  1994-01-31     Completed Date:  1994-01-31     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8007849     Medline TA:  Hepatogastroenterology     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  478-80     Citation Subset:  IM    
Gastroenterology Division, Armed Forces Hospital, Riyadh, Saudi Arabia.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Esophageal and Gastric Varices / complications
Gastroesophageal Reflux / etiology*
Liver Cirrhosis / complications*,  etiology
Middle Aged

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Small polyps found at sigmoidoscopy: are they significant?
Next Document:  The impact of low-residue enteral feeding on the healing of colonic anastomoses.