Document Detail

Frequency of fruit and vegetable consumption and coronary heart disease in France and Northern Ireland: the PRIME study.
MedLine Citation:
PMID:  15613259     Owner:  NLM     Status:  MEDLINE    
Fruit and vegetable consumption is associated with low CHD risk in the USA and Northern Europe. There is, in contrast, little information about these associations in other regions of Europe. The goal of the present study was to assess the relationship between frequency of fruit and vegetable intake and CHD risk in two European populations with contrasting cardiovascular incidence rates; France and Northern Ireland. The present prospective study was in men aged 50-59 years, free of CHD, who were recruited in France (n 5982) and Northern Ireland (n 2105). Fruit and vegetable intake was assessed by a food-frequency questionnaire. Incident cases of acute coronary events and angina were recorded over a 5-year follow-up. During follow-up there was a total of 249 ischaemic events. After adjustment on education level, smoking, physical activity, alcohol consumption, employment status, BMI, blood pressure, serum total and HDL-cholesterol, the relative risks (RR) of acute coronary events were 0.67 (95% CI 0.44, 1.03) and 0.64 (95% CI 0.41, 0.99) in the 2nd and 3rd tertiles of citrus fruit consumption, respectively (P for trend <0.03). Similar results were observed in France and Northern Ireland. In contrast, the RR of acute coronary events for 'other fruit' consumption were 0.70 (95% CI 0.31, 1.56) and 0.52 (95% CI 0.24, 1.14) respectively in Northern Ireland (trend P<0.05) and 1.29 (95% CI 0.69, 2.4) and 1.15 (95% CI 0.68, 1.94) in France (trend P=0.5; interaction P<0.04). There was no evidence for any association between vegetable intake and total CHD events. In conclusion, frequency of citrus fruit, but not other fruits, intake is associated with lower rates of acute coronary events in both France and Northern Ireland, suggesting that geographical or related factors might affect the relationship between fruit consumption and CHD risk.
Luc Dauchet; Jean Ferrières; Dominique Arveiler; John W Yarnell; Fred Gey; Pierre Ducimetière; Jean-Bernard Ruidavets; Bernadette Haas; Alun Evans; Annie Bingham; Philippe Amouyel; Jean Dallongeville
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The British journal of nutrition     Volume:  92     ISSN:  0007-1145     ISO Abbreviation:  Br. J. Nutr.     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2004-12-22     Completed Date:  2005-02-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372547     Medline TA:  Br J Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  963-72     Citation Subset:  IM    
MONICA-Lille, INSERM U 508, Institut Pasteur de Lille, 1 rue du Prof Calmette, 59019 Lille, France.
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MeSH Terms
Acute Disease
Anticarcinogenic Agents / blood
Ascorbic Acid / blood
Coronary Disease / epidemiology*
Eating / physiology
France / epidemiology
Life Style
Middle Aged
Northern Ireland / epidemiology
Prospective Studies
Risk Factors
beta Carotene / analogs & derivatives*,  blood
Reg. No./Substance:
0/Anticarcinogenic Agents; 0/Xanthophylls; 472-70-8/cryptoxanthin; 50-81-7/Ascorbic Acid; 7235-40-7/beta Carotene

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