| Frequency of the fragile X syndrome in Chinese mentally retarded populations is similar to that in Caucasians. | |
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MedLine Citation:
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PMID: 10331588 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Fragile X syndrome is recognized as the most common inherited cause of mental retardation in western countries. The prevalence of the fragile X syndrome in Asian populations is uncertain. We report a multi-institutional collaborative study of molecular screening for the fragile X syndrome from 1,127 Chinese mentally retarded (MR) individuals. We found that 2.8% of the Chinese MR population screened by DNA analysis had the fragile X full mutation. Our screening indicated that the fragile X syndrome prevalence was very close to that of Caucasian subjects. In addition, we found that 62.5% of fragile X chromosomes had a single haplotype for DXS548-FRAXAC1 (21-18 repeats) which was present in only 9.7% of controls. This unique distribution of microsatellite markers flanking the FMR1 CGG repeats suggests that the fragile X syndrome in Chinese populations, as in the Caucasian, may also be derived from founder chromosomes. |
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Authors:
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N Zhong; W Ju; W Xu; L Ye; Y Shen; G Wu; S H Chen; R Jin; X F Hu; A Yang; X Liu; P Poon; C Pang; Y Zheng; L Song; P Zhao; B Fu; H Gu; W T Brown |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: American journal of medical genetics Volume: 84 ISSN: 0148-7299 ISO Abbreviation: Am. J. Med. Genet. Publication Date: 1999 May |
Date Detail:
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Created Date: 1999-06-24 Completed Date: 1999-06-24 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 7708900 Medline TA: Am J Med Genet Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 191-4 Citation Subset: IM |
Affiliation:
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Department of Human Genetics, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York 10314, USA. omrddzhong@aol.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Alleles China / epidemiology European Continental Ancestry Group Female Founder Effect Fragile X Syndrome / epidemiology*, genetics* Genetic Testing Haplotypes Humans Male Mental Retardation / epidemiology*, genetics* X Chromosome / genetics |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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