Document Detail


Frequency of eosinophilia in adult T-cell leukemia/lymphoma.
MedLine Citation:
PMID:  1735088     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cases of adult T-cell leukemia/lymphoma (ATLL) display several peculiar clinical features, including skin rash, hypercalcemia, and an increase in the absolute neutrophil count. The patients rarely have pronounced eosinophilia. In this study, the eosinophilia observed in lymphoproliferative disorders of 62 patients with ATLL, 27 with T-cell lymphoma (TL), and 19 with B-cell lymphoma (BL) was investigated. The incidence of eosinophilia (greater than or equal to 570/microliters) was higher in patients with ATLL than in patients with TL or BL. Thirteen patients with ATLL (21.0%), 3 with TL (11.1%), and 2 with BL (10.5%) had eosinophilia. Of these patients, three with ATLL and one with TL who had a pathologic diagnosis of immunoblastic lymphadenopathy (IBL) showed pronounced eosinophilia up to 10,934/microliters. Because the number of eosinophils in the peripheral blood of these patients correlated both with the number of ATLL cells and the degree of lymphadenopathy and because this fluctuated with chemotherapy, it seems likely that the secretion of some lymphokines by the lymphoma cells is responsible for the eosinophilia.
Authors:
K Murata; Y Yamada; S Kamihira; S Atogami; K Tsukasaki; S Momita; T Amagasaki; N Sadamori; M Tomonaga; K Kinoshita
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Cancer     Volume:  69     ISSN:  0008-543X     ISO Abbreviation:  Cancer     Publication Date:  1992 Feb 
Date Detail:
Created Date:  1992-03-10     Completed Date:  1992-03-10     Revised Date:  2006-04-24    
Medline Journal Info:
Nlm Unique ID:  0374236     Medline TA:  Cancer     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  966-71     Citation Subset:  AIM; IM    
Affiliation:
Department of Hematology, Atomic Disease Institute, Nagasaki University School of Medicine, Japan.
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MeSH Terms
Descriptor/Qualifier:
Antineoplastic Combined Chemotherapy Protocols / therapeutic use
Eosinophilia / complications*
Female
Humans
Leukemia, T-Cell / complications*,  drug therapy
Lymphoma, T-Cell / complications*,  drug therapy
Lymphoproliferative Disorders / complications*
Male
Middle Aged
Retrospective Studies

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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