Document Detail

Frequency encoding in excitable systems with applications to calcium oscillations.
MedLine Citation:
PMID:  7644505     Owner:  NLM     Status:  MEDLINE    
A number of excitable cell types respond to a constant hormonal stimulus with a periodic oscillation in intracellular calcium. The frequency of oscillation is often proportional to the hormonal stimulus, and one says that the stimulus is frequency encoded. Here we develop a theory of frequency encoding in excitable systems and apply it to intracellular calcium oscillations that results from increases in the intracellular level of inositol 1,4,5-triphosphate.
Y Tang; H G Othmer
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  92     ISSN:  0027-8424     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  1995 Aug 
Date Detail:
Created Date:  1995-09-21     Completed Date:  1995-09-21     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  7869-73     Citation Subset:  IM    
Department of Physiology and Biophysics, Cornell University Medical College, New York, NY 10021, USA.
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MeSH Terms
Calcium / metabolism*
Cytoplasm / metabolism
Inositol 1,4,5-Trisphosphate / metabolism
Models, Biological*
Second Messenger Systems
Time Factors
Grant Support
Reg. No./Substance:
7440-70-2/Calcium; 85166-31-0/Inositol 1,4,5-Trisphosphate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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