Document Detail


Frequency-dependent synchrony in locus ceruleus: role of electrotonic coupling.
MedLine Citation:
PMID:  11904447     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Electrotonic coupling synchronizes the spontaneous firing of locus ceruleus (LC) neurons in the neonatal rat brain, whereas in adults, synchronous activity is rare. This report examines the role of action potential frequency on synchronous activity in the adult LC. Decreasing the firing frequency in slices from adult animals facilitated the appearance of subthreshold oscillations and increased the correlation of the membrane potential between pairs of neurons. Conversely, increasing the firing frequency decreased the amplitude and synchrony of the oscillations among pairs. The frequency-dependent synchrony was not observed in slices from neonatal rats, where synchrony was observed at all frequencies, suggesting a developmental change in the properties of the LC network. A mathematical model confirmed that a reduction of the coupling strength among a pair of coupled neurons could generate frequency-dependent synchrony. In slices from adult animals, the combination of electrotonic coupling and firing frequency are the key elements that regulate synchronous firing in this nucleus.
Authors:
Veronica A Alvarez; Carson C Chow; Elisabeth J Van Bockstaele; John T Williams
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  99     ISSN:  0027-8424     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  2002 Mar 
Date Detail:
Created Date:  2002-03-20     Completed Date:  2002-04-24     Revised Date:  2010-09-14    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  United States    
Other Details:
Languages:  eng     Pagination:  4032-6     Citation Subset:  IM    
Affiliation:
Vollum Institute, Oregon Health and Science University, Portland, OR 97201, USA. vernoica.alvarez@hms.harvard.edu
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MeSH Terms
Descriptor/Qualifier:
Action Potentials / physiology*
Aging / physiology
Animals
Animals, Newborn
Electric Conductivity
Locus Coeruleus / cytology,  physiology*
Models, Biological
Neurons / physiology*
Rats
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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