Document Detail


Frequency-dependent response of SI RA-class neurons to vibrotactile stimulation of the receptive field.
MedLine Citation:
PMID:  11794729     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Three types of experiment were carried out on anesthetized monkeys and cats. In the first, spike discharge activity of rapidly adapting (RA) SI neurons was recorded extracellularly during the application of different frequencies of vibrotactile stimulation to the receptive field (RF). The second used the same stimulus conditions to study the response of RA-I (RA) cutaneous mechanoreceptive afferents. The third used optical intrinsic signal (OIS) imaging and extracellular neurophysiological recording methods together, in the same sessions, to evaluate the relationship between the SI optical and RA neuron spike train responses to low- vs high-frequency stimulation of the same skin site. RA afferent entrainment was high at all frequencies of stimulation. In contrast, SI RA neuron entrainment was much lower on average, and was strongly frequency-dependent, declining in near-linear fashion from 6 to 200 Hz. Even at 200 Hz, however, unambiguous frequency-following responses were present in the spike train activity of som
Authors:
B L Whitsel; E F Kelly; M Xu; M Tommerdahl; M Quibrera
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Somatosensory & motor research     Volume:  18     ISSN:  0899-0220     ISO Abbreviation:  Somatosens Mot Res     Publication Date:  2001  
Date Detail:
Created Date:  2002-01-16     Completed Date:  2002-06-14     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8904127     Medline TA:  Somatosens Mot Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  263-85     Citation Subset:  IM    
Affiliation:
Department of Cell and Molecular Physiology, UNC School of Medicine, Chapel Hill, NC 27599, USA. bwhitsel@med.unc.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Cats
Extracellular Space / physiology
Macaca
Mechanoreceptors / physiology
Median Nerve / physiology
Microelectrodes
Neurons, Afferent / physiology
Physical Stimulation
Pyramidal Cells / physiology*
Saimiri
Skin / innervation
Somatosensory Cortex / cytology,  physiology*
Tibial Nerve / physiology
Touch / physiology*
Vibration*
Grant Support
ID/Acronym/Agency:
P01DE07509/DE/NIDCR NIH HHS; R01NS34979/NS/NINDS NIH HHS; R01NS37501/NS/NINDS NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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