Document Detail

Frequency-dependent changes in the paired-pulse index in the hippocampus of the freely moving adult male rat.
MedLine Citation:
PMID:  14980815     Owner:  NLM     Status:  MEDLINE    
The paired-pulse index (PPI) has been widely used as a measure of modulation of cellular excitability in the hippocampal trisynaptic circuit. This paper presents a quantification of the changes in this measure of neuronal modulation as a result of the application of pulse trains having six different train frequencies (0.1, 1, 5, 8, 15, and 30 Hz) to one of the major efferent pathways to the dentate gyrus, the medial perforant path (MPP). Our findings indicate that the modulation of the first leg of the hippocampal trisynaptic circuit is dependent on the frequency of the "burst train" applied to the perforant pathway. This methodological finding is of importance to all investigators studying hippocampal plasticity via LTP or LTD approaches. The different synaptic mechanisms implicated in being responsible for the changes in the PPI are also discussed.
W R Yorns; J H Blaise; J D Bronzino
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Experimental neurology     Volume:  186     ISSN:  0014-4886     ISO Abbreviation:  Exp. Neurol.     Publication Date:  2004 Mar 
Date Detail:
Created Date:  2004-02-24     Completed Date:  2004-04-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370712     Medline TA:  Exp Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  104-8     Citation Subset:  IM    
Department of Engineering, Trinity College, Hartford, CT 006106-3100, USA.
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MeSH Terms
Afferent Pathways / drug effects,  physiology
Electric Stimulation / methods*
Excitatory Postsynaptic Potentials / physiology,  radiation effects
Hippocampus / anatomy & histology,  physiology,  radiation effects*
Long-Term Potentiation / physiology,  radiation effects
Medial Forebrain Bundle / radiation effects
Neural Inhibition / radiation effects
Rats, Sprague-Dawley
Synapses / physiology,  radiation effects*

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