| Frequency of deletion 508 among Irish cystic fibrosis patients. | |
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MedLine Citation:
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PMID: 2210748 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We estimate the incidence of cystic fibrosis in Ireland to be at least 1 case per 1838 live births. We have analysed DNA from 44 Irish CF patients for the presence of deletion 508, using the polymerase chain reaction. The deletion was found in 76% of their chromosomes, and approximately 58% of the patients are homozygous for this deletion. Our results are not significantly different from those found in Canadian or UK patient populations, in which frequencies are higher than those found in Southern European countries. |
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Authors:
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M A De Arce; D Mulherin; P McWilliam; M Lawler; M X FitzGerald; P Humphries |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Human genetics Volume: 85 ISSN: 0340-6717 ISO Abbreviation: Hum. Genet. Publication Date: 1990 Sep |
Date Detail:
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Created Date: 1990-11-21 Completed Date: 1990-11-21 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7613873 Medline TA: Hum Genet Country: GERMANY |
Other Details:
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Languages: eng Pagination: 403-4 Citation Subset: IM |
Affiliation:
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Department of Genetics, Trinity College, Dublin, Ireland. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Chromosome Deletion* Cystic Fibrosis / epidemiology, genetics* Gene Frequency Humans Ireland / epidemiology Polymerase Chain Reaction |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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