Document Detail

Frequency and cytokine phenotype of blood T cells from premature infants responding to staphylococcal enterotoxin B.
MedLine Citation:
PMID:  7596684     Owner:  NLM     Status:  MEDLINE    
The responder cell frequency (RCF) of premature (< 1900 g birth weight) infants' blood lymphocytes, which proliferate in cultures stimulated by staphylococcal enterotoxin B, falls from 1:3400 to about 1:8000 during the first 2 wk of life. Term infants, in contrast, show no fall in RCF. The reduced RCF in the premature infants affected cells that make interferon-gamma more than cells making IL-4. The reduced RCF was accompanied by a fall in the fraction of V beta 3+ T cells that entered cell cycle in stimulated cultures. The RCF of premature infants' T cells was increased in cultures supplemented with irradiated monocytes from adults. Addition of IL-4 (but not IL-2, IL-6, or indomethacin) increased the RCF and fraction of cells entering cell cycle of the premature infants. The data suggest that postnatal environmental factors limit the ability of premature infants' monocytes to support a T-cell response to staphylococcal enterotoxin B in vitro and that this limitation is overcome by adding IL-4.
A R Hayward; M Cosyns; Y Zhang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Pediatric research     Volume:  37     ISSN:  0031-3998     ISO Abbreviation:  Pediatr. Res.     Publication Date:  1995 Apr 
Date Detail:
Created Date:  1995-08-03     Completed Date:  1995-08-03     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  455-9     Citation Subset:  IM    
Department of Pediatrics, University of Colorado Health Sciences Center, Denver 80262, USA.
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MeSH Terms
Cell Cycle / drug effects
Cell Division / drug effects
Enterotoxins / pharmacology*
Indicator Dilution Techniques
Infant, Newborn
Infant, Premature / blood*
Interferon-gamma / analysis*
Interleukin-2 / analysis
Interleukin-4 / analysis*
Interleukin-6 / analysis
Staphylococcus aureus*
T-Lymphocytes / cytology,  drug effects*
Grant Support
Reg. No./Substance:
0/Enterotoxins; 0/Interleukin-2; 0/Interleukin-6; 207137-56-2/Interleukin-4; 39424-53-8/enterotoxin B, staphylococcal; 82115-62-6/Interferon-gamma

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