| Frequency control of cell cycle oscillators. | |
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MedLine Citation:
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PMID: 20851595 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The cell cycle oscillator, based on a core negative feedback loop and modified extensively by positive feedback, cycles with a frequency that is regulated by environmental and developmental programs to encompass a wide range of cell cycle times. We discuss how positive feedback allows frequency tuning, how size and morphogenetic checkpoints regulate oscillator frequency, and how extrinsic oscillators such as the circadian clock gate cell cycle frequency. The master cell cycle regulatory oscillator in turn controls the frequency of peripheral oscillators controlling essential events. A recently proposed phase-locking model accounts for this coupling. |
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Authors:
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Catherine Oikonomou; Frederick R Cross |
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Publication Detail:
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Type: Journal Article; Review Date: 2010-09-28 |
Journal Detail:
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Title: Current opinion in genetics & development Volume: 20 ISSN: 1879-0380 ISO Abbreviation: Curr. Opin. Genet. Dev. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-16 Completed Date: 2011-01-31 Revised Date: 2011-09-22 |
Medline Journal Info:
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Nlm Unique ID: 9111375 Medline TA: Curr Opin Genet Dev Country: England |
Other Details:
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Languages: eng Pagination: 605-12 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Cycle* Circadian Clocks* Gene Expression Regulation Humans Models, Biological |
| Grant Support | |
ID/Acronym/Agency:
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R01 GM047238-16/GM/NIGMS NIH HHS; R01 GM078153-04/GM/NIGMS NIH HHS; R01 GM079207-04/GM/NIGMS NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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