Document Detail


Frequency content of the electrocardiogram. Spatial features and effects of myocardial infarction.
MedLine Citation:
PMID:  3998645     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The frequency content of electrocardiographic signals has been used to define amplifier characteristics and, more recently, to detect myocardial pathology. It was the purpose of this study to evaluate the differences in frequency content of ECG signals recorded from different volume conductor surface sites and to determine the effects of coronary ligation on these spatial features. To do so, 15 isolated perfused rabbit hearts, enclosed within a precisely machined sphere, were studied; ten were examined prior to and 15 minutes after ligation of the anterior descending coronary artery. ECG signals, recorded from 32 surface electrodes, were subjected to Fourier analysis. Prior to occlusion, the frequency content of the different electrode signals varied widely, with a greater variance between electrodes than between hearts (p less than 0.01). This variation was related to a reproducible spatial effect, with records over the basal left ventricle having higher frequency components than waves from other sites. After litigation, ECG records from electrodes over electrodes over ischemic areas showed augmented R-wave amplitude and ST-segment elevation. This was associated with a spatial shift of the control high frequency peak to a site overlying the ischemic lesion. Thus the frequency content of ECG is spatially variable and hence lead-dependent, and this spatial variability is directly affected by acute myocardial infarction.
Authors:
T L Nichols; D M Mirvis
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of electrocardiology     Volume:  18     ISSN:  0022-0736     ISO Abbreviation:  J Electrocardiol     Publication Date:  1985 Apr 
Date Detail:
Created Date:  1985-07-09     Completed Date:  1985-07-09     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0153605     Medline TA:  J Electrocardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  185-93     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Coronary Vessels / surgery
Data Display
Electrocardiography*
Fourier Analysis
Heart / physiopathology
Heart Rate
Ligation
Myocardial Infarction / diagnosis*,  physiopathology
Rabbits
Grant Support
ID/Acronym/Agency:
AM07405/AM/NIADDK NIH HHS; HL00560/HL/NHLBI NIH HHS; HL20597/HL/NHLBI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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