| Frequency of autoantibodies and correlation with HLA-DRB1 genotype in sporadic inclusion body myositis (s-IBM): A population control study. | |
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MedLine Citation:
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PMID: 22554526 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The frequency of myositis-associated and myositis-specific autoantibodies (AAb) was compared in 51 s-IBM patients and a population control group. Non-organ specific AAb (ANA, anti-Ro52, anti-Ro60, anti-La, anti-RNP) but not anti-thyroid peroxidase, anti-tissue transglutaminase or myositis-specific antibodies, were more frequent in s-IBM patients, and 14/51 (27%) had another autoimmune disease (Sjögren's syndrome, thyroiditis, psoriasis, vitiligo). The presence of AAb did not correlate with carriage of HLA-DRB1*0301, but there was a negative correlation between ANA/anti-Ro52 and carriage of HLA-DRB1*1301. The findings in this cohort confirm that patients with sIBM do not show evidence of a muscle-specific humoral immune process but have an increased frequency of non-organ specific AAb and other autoimmune disorders. |
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Authors:
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Arada Rojana-Udomsart; Christine Bundell; Ian James; Alison Castley; Patricia Martinez; Frank Christiansen; Peter Hollingsworth; Frank Mastaglia |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-5-1 |
Journal Detail:
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Title: Journal of neuroimmunology Volume: - ISSN: 1872-8421 ISO Abbreviation: - Publication Date: 2012 May |
Date Detail:
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Created Date: 2012-5-4 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8109498 Medline TA: J Neuroimmunol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 Elsevier B.V. All rights reserved. |
Affiliation:
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Australian Neuro-muscular Research Institute and Centre for Neuromuscular and Neurological disorders, University of Western Australia, Queen Elizabeth II Medical Centre, Perth, Western Australia; Department of Medicine, Yala Hospital, Yala, Thailand. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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