Document Detail

Frequency of atrial septal aneurysm in patients with recent stroke: preliminary results from a multicenter study.
MedLine Citation:
PMID:  11303697     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The role of atrial septal aneurysm (ASA) as a risk factor for cerebral ischemia of unknown etiology is controversial. Recent studies have found an association between ASA and focal ischemic events, while results from other studies suggest a low incidence of embolism in patients with ASA. HYPOTHESIS: The present study was designed to evaluate the frequency of ASA, a minor cardioembolic source, in patients with a recent stroke presenting with normal carotid arteries. METHODS: In all, 394 patients with cerebral ischemic stroke were referred to our institutions. Patients underwent transthracic and transesophageal echocardiography and carotid artery ultrasound examination. The study population included 215 patients without significant arterial disease. Frequency and morphologic characteristics of ASA were evaluated. RESULTS: Transthoracic examination showed ASA in 39 patients (18%), while transesophageal echocardiography showed ASA in 61 patients (28%). A patent foramen ovale was found in 47 patients (21.8%) and was associated with ASA in 40 patients (65.5%). We observed an increased thickness of the aneurysmatic wall (3.80 +/- 1.7 mm) in all patients with ASA. CONCLUSIONS: The present study confirms the relationship between ASA and stroke in patients with normal carotid arteries. The most common abnormality associated with ASA was patent foramen ovale. We suggest that patients who have a stroke in the absence of significant carotid disease undergo transesophageal echocardiography to identify possible underlying septal abnormalities.
A V Mattioli; M Aquilina; A Oldani; C Longhini; G Mattioli
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Publication Detail:
Type:  Journal Article; Multicenter Study    
Journal Detail:
Title:  Clinical cardiology     Volume:  24     ISSN:  0160-9289     ISO Abbreviation:  Clin Cardiol     Publication Date:  2001 Apr 
Date Detail:
Created Date:  2001-04-16     Completed Date:  2001-08-02     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7903272     Medline TA:  Clin Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  297-300     Citation Subset:  IM    
Department of Cardiology, Pierantoni Hospital, Forli, Italy.
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MeSH Terms
Aged, 80 and over
Carotid Arteries / ultrasonography
Coronary Aneurysm / physiopathology,  ultrasonography*
Heart Septal Defects, Atrial / physiopathology,  ultrasonography*
Middle Aged
Stroke / physiopathology,  ultrasonography*
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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