| Frequency of the anti-glutamic acid decarboxylase immunological marker in patients with diabetes duration longer than three years in southern Brazil. | |
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MedLine Citation:
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PMID: 21755246 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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CONTEXT AND OBJECTIVE: The anti-GAD (glutamic acid decarboxylase) antibody is considered to be an important marker for type 1 diabetes mellitus (DM1), with frequency that varies depending on the population studied and the duration of the disease. Therefore, the aim of this study was to determine the frequency of this autoantibody in a group of patients in southern Brazil with DM1 that had been diagnosed more than three years previously. DESIGN AND SETTING: Analytical cross-sectional study with a control group conducted at the Biomedicine Laboratory of Universidade Feevale. METHODS: This study was conducted between June 2007 and December 2008, and 109 individuals were enrolled during this period. Fifty-eight were DM1 patients and 51 were individuals free from DM1 and without any history of diabetes, who constituted the control group. RESULTS: In the DM1 group, the mean age was 27 ± 1.7 years and 50% were men. The mean fasting blood glucose in the DM1 group was 208 ± 15 mg/dl and mean HbA1c (glycosylated hemoglobin) was 8.7 ± 0.25%. In the control group, the mean fasting blood glucose and HbA1c were 82 mg/dl and 5.0% respectively. Thirty-seven individuals with DM1 (63.8%) were positive for anti-GAD, and this proportion was significantly larger than in the control group. CONCLUSIONS: These results show the high prevalence of anti-GAD in the population of diabetic patients in southern Brazil, thus indicating that the antibody was still present a long time after the disease had been diagnosed. |
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Authors:
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Marina Carolina Moreira; Gustavo Müller Lara; Rafael Linden; Luciane Rosa Feksa; Rejane Giacomelli Tavares; Sabrina Esteves de Matos Almeida; Daiane Bolzan Berlese |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: São Paulo medical journal = Revista paulista de medicina Volume: 129 ISSN: 1806-9460 ISO Abbreviation: Sao Paulo Med J Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-07-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100897261 Medline TA: Sao Paulo Med J Country: Brazil |
Other Details:
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Languages: eng Pagination: 130-3 Citation Subset: IM |
Affiliation:
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Universidade Feevale, Novo Hamburgo, Rio Grande do Sul, Brazil. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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