| Frequency of abnormalities of cortisol secretion and water metabolism in patients with small cell carcinoma of the lung and other malignancies. | |
| | |
MedLine Citation:
|
PMID: 6280929 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Previous studies have suggested that ectopic production of adrenocorticotropic hormone (ACTH) or antidiuretic hormone (ADH) may occur commonly in patients with small cell carcinoma of the lung (SCCL) and that evidence of such production may be elicited only by provocative tests of water excretion and adrenal function. We studied 28 patients with SCCL and 29 patients with other cancers. Adrenal function, assessed by measuring the 8 am plasma cortisol, the 8 am to 4 pm diurnal variation in plasma cortisol, and the suppressibility of the 8 am plasma cortisol following administration of 1 mg of dexamethasone, was found to be abnormal in 28.5, 71, and 25 percent, respectively, of the patients with SCCL, compared with 18, 65, and 29.5 percent in patients with other types of cancer (P greater than 0.3). The possibility of ectopic ADH secretion was assessed by a standard water loading test, which showed excretion impairment in 60 percent of patients with SCCL and 68 percent of patients with other cancers (P greater than 0.9). Neither the stage of neoplastic disease, sites of metastatic deposits, nor performance status of the patients correlated with abnormalities of water and cortisol metabolism, indicating that such abnormalities are common in patients with all types of cancer. These data do not suggest that subclinical disturbances of adrenal function or water excretion are characteristic of any histologic type of cancer. The precise mechanism(s) underlying these abnormalities are unknown. |
| | |
Authors:
|
D L Trump; M D Abeloff; T H Hsu |
Related Documents
:
|
3465159 - Patients with acromegaly come from tall families. 9365329 - Incidental pituitary macroadenoma: a population-based study. 3766049 - Transsphenoidal microsurgery for cushing's disease. 20446239 - Adrenomedullary function in patients with nonclassic congenital adrenal hyperplasia. 3111169 - Growth hormone deficiency in adults--an indication for therapy? 19898989 - Effectiveness of self- or partner-administration of an extended-release aqueous-gel for... 11306859 - Double dissociations between neglect tests: possible relation to lesion site. 1522619 - First trimester findings in pregnancies after in vitro fertilization. 20377709 - Multi-detector ct angiography for lower gastrointestinal bleeding: can it select patien... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Chest Volume: 81 ISSN: 0012-3692 ISO Abbreviation: Chest Publication Date: 1982 May |
Date Detail:
|
Created Date: 1982-07-22 Completed Date: 1982-07-22 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0231335 Medline TA: Chest Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 576-80 Citation Subset: AIM; IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adrenocorticotropic Hormone
/
metabolism Adult Aged Body Water / metabolism* Carcinoma, Small Cell / metabolism* Circadian Rhythm / drug effects Dexamethasone / pharmacology Humans Hydrocortisone / metabolism* Lung Neoplasms / metabolism* Middle Aged Prognosis Vasopressins / metabolism |
| Grant Support | |
ID/Acronym/Agency:
|
CA-17970/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
11000-17-2/Vasopressins; 50-02-2/Dexamethasone; 50-23-7/Hydrocortisone; 9002-60-2/Adrenocorticotropic Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Genetic analysis of tumorigenesis. VIII. Suppression of SV40 transformation in cell hybrids and cyto...
Next Document: Adenovirus bronchiolitis in Manitoba: epidemiologic, clinical, and radiologic features.