Document Detail


Frequency of Symptomatic Zinc Deficiency in Very Low Birth Weight Infants.
MedLine Citation:
PMID:  22821297     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Current concepts on zinc requirements for premature infants rely on studies dating back more than 20 years. Given that nowadays more premature infants frequently survive we aimed to obtain recent frequency data on zinc deficiency in very low birth weight (VLBW) infants.226 VLBW infants born between July 2005 and December 2009 were retrospectively included in this study. Mean gestational age (GA) was 28.7 weeks (range 23+0 to 38+0) and mean birth weight 1120g (range 354-1495). All infants received zinc supplementation according to the ESPGHAN guidelines. 26 (11.5%) patients showed clinical signs for zinc deficiency of whom 15 had serum zinc concentrations < 50µg/dl, 9 between 50 and 70 µg/dl and 2 > 70 µg/dl. Infants presenting with dermatitis had significantly lower concentrations (mean 26.7 µg/dl, range 19-31) when compared to infants with diarrhoea or isolated peripheral oedema (35.3 µg/dl and 51.8 µg/dl respectively). Strongest independent risk factors were low GA, being small for GA and suffering from intestinal resection due to necrotizing enterocolitis. Frequency of zinc concentrations <50 µg/dl were calculated to be 6.6% in VLBW infants.Even though current guidelines for zinc supplementation were followed the frequency of zinc deficiency was found to be unexpectedly high in ELBW and SGA infants. Despite the retrospective nature of this single centre study, our data strongly suggest that recommendations on zinc supplementation in ELBW and SGA infants should be reviewed.
Authors:
K Wulf; A Wilhelm; M Spielmann; S Wirth; A C Jenke
Related Documents :
6774307 - Newer trends in continuous monitoring of critically ill infants and children.
11756647 - Predictive value of skin color for illness severity in the high-risk newborn.
11735707 - Dermoscopic classification of atypical melanocytic nevi (clark nevi).
2305737 - Evaluations of diapers containing absorbent gelling material with conventional disposab...
12220437 - Sibship stability of genotype and phenotype in myotonic dystrophy.
16263997 - Regional variation in rates of low birth weight.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-20
Journal Detail:
Title:  Klinische Padiatrie     Volume:  -     ISSN:  1439-3824     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0326144     Medline TA:  Klin Padiatr     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© Georg Thieme Verlag KG Stuttgart · New York.
Affiliation:
HELIOS Children's Hospital Wuppertal, Neonatology, Wuppertal, Germany.
Vernacular Title:
Häufigkeit der Zinkdefizienz bei extrem untergewichtigen Neugeborenen.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Timely MMR Vaccination in Infancy: Influence of Attitudes and Medical Advice on the Willingness to V...
Next Document:  Genetic Prognostic Factors in Childhood Acute Myeloid Leukemia.