| Frequency of RAS and p53 mutations in acute promyelocytic leukemias. | |
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MedLine Citation:
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PMID: 8124213 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The frequency of RAS and p53 mutations was investigated in 30 acute promyelocytic leukemias by single strand conformation polymorphism analysis and direct sequencing of genomic DNA. Only two cases bore N-RAS codon 12 mutations and none had p53 mutations responsible for aminoacid substitutions. It would, therefore, seem that neither RAS nor p53 are involved in acute promyelocytic leukemogenesis. |
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Authors:
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L Longo; D Trecca; A Biondi; F Lo Coco; F Grignani; A T Maiolo; P G Pelicci; A Neri |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Leukemia & lymphoma Volume: 11 ISSN: 1042-8194 ISO Abbreviation: Leuk. Lymphoma Publication Date: 1993 Nov |
Date Detail:
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Created Date: 1994-04-11 Completed Date: 1994-04-11 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9007422 Medline TA: Leuk Lymphoma Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 405-10 Citation Subset: IM |
Affiliation:
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Istituto Clinica Medica I, University of Perugia, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Base Sequence Genes, p53* Genes, ras* Humans Leukemia, Promyelocytic, Acute / etiology, genetics* Molecular Sequence Data Mutation* |
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