Document Detail

Frequency and predictors of drug-eluting stent use in saphenous vein bypass graft percutaneous coronary interventions: a report from the American College of Cardiology National Cardiovascular Data CathPCI registry.
MedLine Citation:
PMID:  20965466     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: We examined a large registry to determine the frequency and factors associated with drug-eluting stents (DES) use in saphenous vein graft (SVG) in contemporary practice.
BACKGROUND: Prospective trials comparing DES with bare-metal stents in SVG lesions have provided conflicting conclusions regarding safety and efficacy leading to potential variation in stent choice for these lesions.
METHODS: We analyzed the frequency and factors associated with DES use in patients undergoing SVG stenting from January 1, 2004, to March 31, 2009, in the National Cardiovascular Data Registry. Generalized estimating equations logistic regression modeling was used to generate independent variables associated with DES use in SVGs.
RESULTS: During the study period, percutaneous coronary intervention (PCI) of a SVG represented 5.7% of the total PCI volume (91,355 of 1,596,966). Of the 84,875 patients who received a SVG stent, a DES was used in 64.5%. From 2005 to 2009, DES use in SVG PCI changed from 80% to 62%. Unfractionated heparin was used in 46%, enoxaparin in 17%, bivalirudin in 42%, and a glycoprotein IIb/IIIa inhibitor in 40% of cases. On multivariable analysis, several parameters (including the period, multivessel PCI, prior PCI, no acute myocardial infarction, and no smoking) were associated with DES use.
CONCLUSIONS: Currently, DES are used in nearly two-thirds of SVG interventions. Several clinical parameters (such as the period of implantation and the complexity of coronary artery disease) are associated with the decision to implant a DES in these challenging lesions.
Emmanouil S Brilakis; Tracy Y Wang; Sunil V Rao; Subhash Banerjee; Steven Goldman; Kendrick Shunk; Biswajit Kar; David R Holmes; David Dai; Chee T Chin; Tina M Harding; Matthew T Roe
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  JACC. Cardiovascular interventions     Volume:  3     ISSN:  1876-7605     ISO Abbreviation:  JACC Cardiovasc Interv     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-22     Completed Date:  2011-02-09     Revised Date:  2014-09-05    
Medline Journal Info:
Nlm Unique ID:  101467004     Medline TA:  JACC Cardiovasc Interv     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1068-73     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.
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MeSH Terms
Aged, 80 and over
Angioplasty, Balloon, Coronary / adverse effects,  instrumentation*,  mortality
Chi-Square Distribution
Coronary Artery Bypass / adverse effects*,  mortality
Coronary Artery Disease / surgery*
Drug-Eluting Stents*
Graft Occlusion, Vascular / etiology,  mortality,  therapy*
Hospital Mortality
Logistic Models
Middle Aged
Risk Assessment
Risk Factors
Saphenous Vein / transplantation*
Societies, Medical
Treatment Outcome
United States

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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