| Frequency of Candida spp. in the oral cavity of Brazilian HIV-positive patients and correlation with CD4 cell counts and viral load. | |
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MedLine Citation:
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PMID: 18781394 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of this study was to evaluate the prevalence of Candida spp., and particularly C. dubliniensis, among oral isolates from Brazilian HIV-positive patients correlating these results with CD4 cell counts and viral load. Forty-five individuals (23 female and 22 male) diagnosed as HIV-positive by ELISA and Western-blot, under anti-retroviral therapy for at least 1 year and without oral candidosis signals were included in the study. The control group was constituted by 45 healthy individuals, matched to the test group in relation to age, gender, and oral conditions. Oral rinses were collected and the identification was performed by phenotypic tests. The existence of C. dubliniensis among the isolates was analyzed using a validated multiplex PCR assay. Candida spp. were detected at significantly higher number in the oral cavity of HIV-positive patients in relation to the controls (P = 0.0008). C. albicans was the most frequently isolated species in both groups. In the HIV group, C. glabrata, C. lipolytica, C. krusei, C. guilliermondii, and C. parapsilosis were also identified. In the control group, we additionally identified C. tropicalis and C. dubliniensis. Two isolates (1.9%, 2/108) from control individuals were identified as C. dubliniensis and this species was not verified in the HIV group. Candida spp. counts were statistically lower (P = 0.0230) in the oral cavity of patients with low viral load (<400 copies/mm(3)). Candida spp. counts did not differ statistically among groups with different levels of CD4 cells counts (P = 0.1068). |
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Authors:
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G N Back-Brito; A J Mota; T C Vasconcellos; S M R Querido; A O C Jorge; A S M Reis; I Balducci; Cristiane Yumi Koga-Ito |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-09-10 |
Journal Detail:
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Title: Mycopathologia Volume: 167 ISSN: 0301-486X ISO Abbreviation: Mycopathologia Publication Date: 2009 Feb |
Date Detail:
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Created Date: 2009-01-15 Completed Date: 2009-04-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7505689 Medline TA: Mycopathologia Country: Netherlands |
Other Details:
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Languages: eng Pagination: 81-7 Citation Subset: IM |
Affiliation:
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Department of Oral Biosciences and Diagnosis, Laboratory of Microbiology, São José dos Campos Dental School, São Paulo State University (UNESP), Av. Engenheiro Francisco José Longo, 777 São José dos Campos, Sao Paulo, Brazil. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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AIDS-Related Opportunistic Infections
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epidemiology,
immunology,
microbiology* Adult Aged Brazil CD4 Lymphocyte Count Candida / isolation & purification* Candida albicans / isolation & purification Candida glabrata / isolation & purification Candida tropicalis / isolation & purification Candidiasis, Oral / epidemiology, immunology, microbiology* Female HIV Infections / epidemiology, immunology, microbiology* Humans Male Middle Aged Mouth / microbiology Prevalence Viral Load* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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