Document Detail


Frequencies of dendritic cells (myeloid DC and plasmacytoid DC) and their ratio reduced in pregnant women: comparison with umbilical cord blood and normal healthy adults.
MedLine Citation:
PMID:  14630396     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
CD11c(+) peripheral blood myeloid dendritic cells (MDC), and CD123(bright) plasmacytoid cells (PDC), are two human dendritic cell (DC) populations. In the present study, the percentages of MDC [lin(-)/HLA-DR(+)/CD123(-)/CD11c(+)] and PDC [lin(-)/HLA-DR(+)/CD123(bright)] in a peripheral blood (PB) sample obtained from women at the time of delivery and in their umbilical cord blood (UCB) were compared with those in the PB of healthy volunteers. The percentages of MDC and PDC were determined by four-color flow cytometry. The percentages of MDC and PDC were significantly lower in the PB obtained at delivery (MDC, 0.11% +/- 0.08%; PDC, 0.06% +/- 0.06%) and in the UCB (MDC, 0.15% +/- 0.03%; PDC, 0.05% +/- 0.05%) than in the PB of the controls (males, 0.28% +/- 0.12%, 0.11% +/- 0.06%; females, 0.32% +/- 0.13%, 0.11% +/- 0.07%). Among the pregnant women at delivery, there were significant correlations between the percentage of MDC or percentage of PDC in the PB at delivery and the respective parameter in the UCB. The PB of other pregnant women, at 20-35 weeks of gestational age, also indicated significantly low percentages of MDC and PDC (0.1% +/- 0.1%, 0.06% +/- 0.07%). The ratio of MDC/PDC was not reduced in the UCB (4.25 +/- 2.74), but was reduced in the PB obtained at delivery and the PB obtained during pregnancy (0.79 +/- 0.91) in comparison with that in age-matched, nonpregnant females (3.96 +/- 2.95). It was assumed that reduction of MDC during pregnancy plays an important role in maintaining immune tolerance against the embryo.
Authors:
Yoko Ueda; Masao Hagihara; Ayako Okamoto; Ayako Higuchi; Akiko Tanabe; Kaori Hirabayashi; Shunichiro Izumi; Tsunehisa Makino; Shunichi Kato; Tomomitsu Hotta
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Human immunology     Volume:  64     ISSN:  0198-8859     ISO Abbreviation:  Hum. Immunol.     Publication Date:  2003 Dec 
Date Detail:
Created Date:  2003-11-21     Completed Date:  2004-07-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8010936     Medline TA:  Hum Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1144-51     Citation Subset:  IM    
Affiliation:
Department of Hematology and Oncology, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adult
Antigens, CD11c / immunology*
Blood Cell Count
Dendritic Cells / cytology,  immunology*
Female
Fetal Blood / cytology*
Flow Cytometry
Humans
Male
Myeloid Cells / cytology,  immunology*
Pregnancy
Receptors, Interleukin-4 / immunology*
Chemical
Reg. No./Substance:
0/Antigens, CD11c; 0/Receptors, Interleukin-4

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