Document Detail

Frequencies of the G-protein beta3 subunit C825T polymorphism and the delta 32 mutation of the chemokine receptor-5 in patients with multiple sclerosis.
MedLine Citation:
PMID:  12270649     Owner:  NLM     Status:  MEDLINE    
In the pathogenesis of multiple sclerosis (MS) genetic factors are known to influence autoreactive T-cell-actions like proliferation and chemotaxis across the blood-brain barrier via chemokine receptors (CCR) and G-protein coupled activating mechanisms. For the first time, we studied the frequencies of a recently described C825T polymorphism in the G-protein encoding gene for the beta3 subunit (GNB3) together with frequencies of a 32-base-pair deletion in the CCR5 gene (delta32 CCR5) in patients with MS (n = 253: relapsing-remitting (RR), n = 124 and chronic progressive course, n = 129). Apart from a trend to a reduced frequency of delta32 CCR5 and increased GNB3 825T polymorphism in primary chronic progressive patients, numbers did not reach statistical significance in any group of MS. These results could not support differences in the genetic background of MS based on that CCR5 mutation or the described GNB3 polymorphism.
Claus G Haase; Stephan Schmidt; Pedro M Faustmann
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neuroscience letters     Volume:  330     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  2002 Sep 
Date Detail:
Created Date:  2002-09-24     Completed Date:  2002-12-13     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  293-5     Citation Subset:  IM    
Copyright Information:
Copyright 2002 Elsevier Science Ltd.
Department of Neurology, University Hospital Essen, Essen, Germany.
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MeSH Terms
Disease Progression
Genetic Predisposition to Disease
Heterotrimeric GTP-Binding Proteins / genetics*
Middle Aged
Multiple Sclerosis / genetics*
Polymorphism, Genetic
Receptors, CCR5 / genetics*
Reg. No./Substance:
0/G-protein beta3 subunit; 0/Receptors, CCR5; 9007-49-2/DNA; EC GTP-Binding Proteins

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