Document Detail


Frequencies of FoxP3+ naive T cells are related to both viral load and naive T cell proliferation responses in HIV disease.
MedLine Citation:
PMID:  21653240     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
HIV infection results in depletion and dysfunction of naïve CD4(+) T cells. The mechanisms underlying these deficiencies are not understood. We investigated the frequencies of CD4(+) naïve subsets in HIV disease as defined by expression of CD25 and/or FoxP3 and the relationship of these frequencies to naïve T cell proliferation function. We observed increased proportions of CD25(+)FoxP3(+) and CD25(+)FoxP3(-) cells and decreased proportions of CD25(-)FoxP3(-) cells within the naïve CD4(+) cell compartment from HIV-infected persons compared with findings in healthy donors. These perturbations were related to higher plasma HIV RNA levels but not with higher immune activation, as measured by the proportions of CD38(+) memory CD4(+) T cells. Naïve T cell proliferation responses to mitogen stimulation were inversely related to the frequencies and absolute numbers of FoxP3(+) naïve T cells. MDA, a marker of oxidative stress, and sCD14, a marker of monocyte activation and a surrogate for microbial translocation, were increased in serum samples from HIV(+) donors; however, neither marker was related to naïve T cell function in HIV(+) donors. These observations suggest that alterations in naïve T cell subset frequencies could contribute to naïve T cell dysfunction in HIV disease, but these alterations are not necessarily the result of chronic immune activation.
Authors:
Benigno Rodriguez; Douglas A Bazdar; Nicholas Funderburg; Robert Asaad; Angel A Luciano; Gopal Yadavalli; Robert C Kalayjian; Michael M Lederman; Scott F Sieg
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2011-06-07
Journal Detail:
Title:  Journal of leukocyte biology     Volume:  90     ISSN:  1938-3673     ISO Abbreviation:  J. Leukoc. Biol.     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-09-01     Completed Date:  2011-10-24     Revised Date:  2013-06-28    
Medline Journal Info:
Nlm Unique ID:  8405628     Medline TA:  J Leukoc Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  621-8     Citation Subset:  IM    
Affiliation:
Department of Medicine, Case Western Reserve University, Cleveland, OH, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
CD4-Positive T-Lymphocytes / immunology*,  metabolism,  virology
Case-Control Studies
Cytokines / metabolism
Flow Cytometry
Forkhead Transcription Factors / metabolism*
HIV Infections / immunology,  metabolism,  virology
HIV-1 / immunology,  metabolism
Humans
Immunologic Memory
Interleukin-2 Receptor alpha Subunit / metabolism
Lymphocyte Activation
Male
Middle Aged
T-Lymphocytes, Regulatory / immunology*,  metabolism,  virology
Viral Load*
Grant Support
ID/Acronym/Agency:
AI-076174/AI/NIAID NIH HHS; AI-36219/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Cytokines; 0/FOXP3 protein, human; 0/Forkhead Transcription Factors; 0/Interleukin-2 Receptor alpha Subunit
Comments/Corrections

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