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Freeze-fracture observations of the lactating rat mammary gland. Membrane events during milk fat secretion.
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MedLine Citation:
PMID:  632326     Owner:  NLM     Status:  MEDLINE    
Membrane events during milk fat secretion were analyzed by freeze-fracture of the rat mammary gland. Two modes of milk fat secretion were observed: extrusion of fat droplets surrounded by a portion of the apical plasma membrane of the alveolar epithelial cells and, less frequently, release into the alveolar lumen of fat droplets contained in intracytoplasmic vacuoles. The extrusion process consists of two asynchronous events: clearing of membrane particles (probably including integral membrane proteins) and bulging of the apical plasma membrane. Most fat droplets are extruded with a bilayer membrane envelope (milk fat globule membrane) partially devoid of particles. The segregation of membrane particles may represent the onset of a process of structural degradation of the milk fat globule membrane.
A Peixoto de Menezes; P Pinto da Silva
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of cell biology     Volume:  76     ISSN:  0021-9525     ISO Abbreviation:  J. Cell Biol.     Publication Date:  1978 Mar 
Date Detail:
Created Date:  1978-05-17     Completed Date:  1978-05-17     Revised Date:  2010-09-02    
Medline Journal Info:
Nlm Unique ID:  0375356     Medline TA:  J Cell Biol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  767-78     Citation Subset:  IM    
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MeSH Terms
Cell Membrane / ultrastructure
Freeze Fracturing
Mammary Glands, Animal / physiology,  ultrastructure*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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Journal Information
Journal ID (nlm-ta): J Cell Biol
ISSN: 0021-9525
ISSN: 1540-8140
Publisher: The Rockefeller University Press
Article Information
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Print publication date: Day: 1 Month: 3 Year: 1978
Volume: 76 Issue: 3
First Page: 767 Last Page: 778
ID: 2110004
Publisher Id: 78130219
PubMed Id: 632326

Freeze-fracture observations of the lactating rat mammary gland. Membrane events during milk fat secretion

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