Document Detail

Free wall rupture following rescue angioplasty and intravenous abciximab for failed thrombolysis.
MedLine Citation:
PMID:  11501328     Owner:  NLM     Status:  MEDLINE    
Early thrombolytic therapy reduces the risk of cardiac rupture but delayed thrombolysis may increase this risk, despite improving overall survival. The mechanism appears to be related to both unsuccessful early reperfusion and haemorrhagic transformation following delayed reperfusion. The effect of antiplatelet therapy with glycoprotein IIb-IIIa receptor blockers (abciximab) on cardiac rupture is unknown. It is possible that they may contribute to cardiac rupture by promoting haemorrhagic transformation of the infarcted area. In this report we describe a 57 year old man who underwent emergency coronary angioplasty and stenting following failed thrombolytic therapy for an acute anterior myocardial infarction. A suboptimal result was obtained which necessitated an intravenous bolus of abciximab followed by an infusion. He abruptly developed electromechanical dissociation. Echocardiogram confirmed pericardial tamponade and a pericardial drain was inserted but the patient could not be resuscitated. Postmortem examination confirmed a large transmural rupture of the infarcted anterior wall which had undergone haemorrhagic transformation.
K P Balachandran; K G Oldroyd
Related Documents :
3632118 - Successful management of left ventricular rupture following myocardial revascularization.
17067988 - Free-wall rupture of the myocardium following infarction: a changing clinical portrait ...
3191588 - Angiographic features in the infarct-related artery after intracoronary urokinase follo...
10618338 - Is preinfarction angina related to the presence or absence of coronary plaque rupture?
3828 - Carotid body control of coronary flow, myocardial oxidative metabolism, and cardiac cat...
15458018 - Prevention of work-related decompression illness events by detection of a cardiac right...
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Scottish medical journal     Volume:  46     ISSN:  0036-9330     ISO Abbreviation:  Scott Med J     Publication Date:  2001 Jun 
Date Detail:
Created Date:  2001-08-14     Completed Date:  2001-12-13     Revised Date:  2013-05-24    
Medline Journal Info:
Nlm Unique ID:  2983335R     Medline TA:  Scott Med J     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  87-8     Citation Subset:  IM    
Department of Cardiology, Hairmyres Hospital, East Kilbride, Glasgow G75 8RG.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Angioplasty, Balloon, Coronary*
Antibodies, Monoclonal / administration & dosage,  adverse effects*,  therapeutic use
Fatal Outcome
Heart Rupture, Post-Infarction / chemically induced*
Immunoglobulin Fab Fragments / administration & dosage,  adverse effects*,  therapeutic use
Infusions, Intravenous
Middle Aged
Myocardial Infarction / therapy*
Platelet Aggregation Inhibitors / administration & dosage,  adverse effects*,  therapeutic use
Thrombolytic Therapy*
Treatment Failure
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Immunoglobulin Fab Fragments; 0/Platelet Aggregation Inhibitors; X85G7936GV/abciximab

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Mortality during the winter flu epidemic--two cases of death associated with self-medication.
Next Document:  Proactive safety surveillance.