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Free thyroxine and thyroid-stimulating hormone reference intervals in very low birth weight infants at 3-6weeks of life with the Beckman Coulter Unicel DxI 800.
MedLine Citation:
PMID:  24125878     Owner:  NLM     Status:  Publisher    
OBJECTIVES: To establish reference intervals for thyroid stimulating hormone (TSH) and free thyroxine (FT4) at 3-6weeks of age in very low birth weight (VLBW) infants with the Beckman Coulter Unicel DxI 800 by gender, birth weight (BW) and gestational age (GA) subgroups.
DESIGN AND METHODS: A 4year retrospective cohort of 308 VLBW infants (GA 27.9weeks, BW 992.3 grams) was studied. All blood samples for TSH and FT4 were analyzed using the modified fTSH2 (TSH) and two-step competitive enzyme immunoassay (FT4). Reference intervals were evaluated according to the most recent Clinical and Laboratory Standards Institute(CLSI) guidelines.
RESULTS: The study provides non-parametric 95% reference intervals with associated 90% confidence intervals for FT4 and TSH derived from 308 infants screened at a median of 31days. The reference interval for this population is TSH 1.14-11.04mIU/L and FT4 10.9-21.4pmol/L. TSH statistically differed according to birth weight (<1000g vs 1000-1499g) while FT4 differed according to gender and gestational age at time of testing (<32weeks vs ≥32weeks); however, these differences were not clinically significant and a single reference interval for each analyte is reported.
CONCLUSION: The results of this study highlight the importance and complexity of establishing appropriate reference intervals for thyroid function testing for the preterm population.
Xiaoli Sun; Brigitte Lemyre; Xiaoqin Nan; Joann Harrold; Sherry L Perkins; Sarah E Lawrence; Nick Barrowman
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-10-11
Journal Detail:
Title:  Clinical biochemistry     Volume:  -     ISSN:  1873-2933     ISO Abbreviation:  Clin. Biochem.     Publication Date:  2013 Oct 
Date Detail:
Created Date:  2013-10-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0133660     Medline TA:  Clin Biochem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2013.
Division of Neonatology, Children's Hospital of Eastern Ontario (CHEO), 401 Smyth Road, Ottawa, Ontario, K1H 8L1. Electronic address:
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