Document Detail

Free thyroxin measured in dried blood spots from normal, low-birth-weight, and hypothyroid neonates.
MedLine Citation:
PMID:  1764786     Owner:  NLM     Status:  MEDLINE    
We have adapted a new radioimmunoassay for free thyroxin (FT4) measurement in dried blood spots for use in neonatal screening for hypothyroidism. The method is easy, fast, and cheap. Within-assay and between-assay CVs are respectively 9.6% and 13.2%. In 997 neonates three days postpartum with normal thyrotropin concentrations, the mean FT4 concentration was 27.2 pmol/L (SD 7.3 pmol/L). There was no significant difference in mean FT4 concentration between boys and girls. FT4 concentrations increased linearly with birth weight or with gestational age, as expressed by multiple linear regression: FT4 (pmol/L) = 0.0016 birth weight (g) + 0.6931 gestational age (weeks) - 4.8772. Only gestational age significantly affected the FT4 value. For five hypothyroid infants tested on day three postpartum, FT4 values were all below the 1st percentile of values from healthy neonates. Thus, when the neonatal concentration of thyrotropin is above normal, FT4 measured in the same sample can provide a reliable earlier diagnosis of hypothyroidism.
F Lemonnier; J Masson; D Laroche; J Travert; G Travert
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical chemistry     Volume:  37     ISSN:  0009-9147     ISO Abbreviation:  Clin. Chem.     Publication Date:  1991 Dec 
Date Detail:
Created Date:  1992-02-18     Completed Date:  1992-02-18     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9421549     Medline TA:  Clin Chem     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2114-7     Citation Subset:  IM    
Service de Biophysique et Médecine Nucléaire, C.H.R.U. de Caen, France.
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MeSH Terms
Birth Weight
Gestational Age
Hypothyroidism / blood*
Infant, Low Birth Weight / blood*
Infant, Newborn
Neonatal Screening / methods*
Radioimmunoassay / methods,  statistics & numerical data
Reference Values
Regression Analysis
Thyroxine / blood*
Reg. No./Substance:

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