Document Detail

Free-space fluorescence molecular tomography utilizing 360 degrees geometry projections.
MedLine Citation:
PMID:  17356660     Owner:  NLM     Status:  MEDLINE    
Fluorescence tomography of diffuse media can yield optimal three-dimensional imaging when multiple projections over 360 degrees geometries are captured, compared with limited projection angle systems such as implementations in the slab geometry. We demonstrate how it is possible to perform noncontact, 360 degrees projection fluorescence tomography of mice using CCD-camera-based detection in free space, i.e., in the absence of matching fluids. This approach achieves high spatial sampling of photons propagating through tissue and yields a superior information content data set compared with fiber-based 360 degrees implementations. Reconstruction feasibility using 36 projections in 10 degrees steps is demonstrated in mice.
Nikolaos Deliolanis; Tobias Lasser; Damon Hyde; Antoine Soubret; Jorge Ripoll; Vasilis Ntziachristos
Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Optics letters     Volume:  32     ISSN:  0146-9592     ISO Abbreviation:  Opt Lett     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-03-14     Completed Date:  2007-04-24     Revised Date:  2007-12-03    
Medline Journal Info:
Nlm Unique ID:  7708433     Medline TA:  Opt Lett     Country:  United States    
Other Details:
Languages:  eng     Pagination:  382-4     Citation Subset:  IM    
Laboratory for Biooptics and Molecular Imaging, Center for Molecular Imaging Research, Massachusetts General Hospital & Harvard Medical School, Charlestown, MA 02129, USA.
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MeSH Terms
Equipment Design
Equipment Failure Analysis
Image Enhancement / instrumentation*
Image Interpretation, Computer-Assisted / instrumentation*
Imaging, Three-Dimensional / instrumentation*
Microscopy, Confocal / instrumentation*,  methods
Microscopy, Fluorescence / instrumentation*,  methods
Reproducibility of Results
Sensitivity and Specificity
Tomography, Optical / instrumentation*,  methods
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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