Document Detail

Free radicals and the pancreatic acinar cells: role in physiology and pathology.
MedLine Citation:
PMID:  16321797     Owner:  NLM     Status:  MEDLINE    
Reactive oxygen and nitrogen species (ROS and RNS) play an important role in signal transduction and cell injury processes. Nitric oxide synthase (NOS)-the key enzyme producing nitric oxide (NO)-is found in neuronal structures, vascular endothelium and, possibly, in acinar and ductal epithelial cells in the pancreas. NO is known to regulate cell homeostasis, and its effects on the acinar cells are reviewed here. ROS are implicated in the early events within the acinar cells, leading to the development of acute pancreatitis. The available data on ROS/RNS involvement in the apoptotic and necrotic death of pancreatic acinar cells will be discussed.
M Chvanov; O H Petersen; A Tepikin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Philosophical transactions of the Royal Society of London. Series B, Biological sciences     Volume:  360     ISSN:  0962-8436     ISO Abbreviation:  Philos. Trans. R. Soc. Lond., B, Biol. Sci.     Publication Date:  2005 Dec 
Date Detail:
Created Date:  2005-12-02     Completed Date:  2006-06-22     Revised Date:  2013-06-07    
Medline Journal Info:
Nlm Unique ID:  7503623     Medline TA:  Philos Trans R Soc Lond B Biol Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  2273-84     Citation Subset:  IM    
The University of Liverpool The Physiological Laboratory Crown Street, Liverpool L69 3BX, UK.
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MeSH Terms
Apoptosis / physiology*
Free Radicals / metabolism*
Homeostasis / physiology*
Models, Biological*
Nitric Oxide Synthase / metabolism
Pancreas / metabolism,  pathology*,  physiology*
Signal Transduction / physiology*
Reg. No./Substance:
0/Free Radicals; EC Oxide Synthase

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