| Free radicals in licorice-flavored sweets can Be detected noninvasively using low frequency electron paramagnetic resonance after oral administration to mice. | |
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MedLine Citation:
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PMID: 10867059 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The observation of the fate of free radicals coming from food after oral administration could be important in evaluating their reactivity in vivo. The aim of this study was to demonstrate that it is feasible to detect directly in vivo free radicals coming from food with the use of low frequency electron paramagnetic resonance (EPR) spectroscopy. Because polyphenols are easily oxidized into stable radicals, we assumed that these radicals could be detected in food. We chose licorice, which contains several types of polyphenols. The presence of free radicals was demonstrated in licorice-flavored sweets. Using low frequency EPR spectroscopy, we detected these free radicals directly and noninvasively after oral administration to mice. These radicals were rather stable in the guts of the mice. This study is the first report demonstrating noninvasively the presence of free radicals in vivo coming from food. |
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Authors:
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B Gallez; C Baudelet; R Debuyst |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of nutrition Volume: 130 ISSN: 0022-3166 ISO Abbreviation: J. Nutr. Publication Date: 2000 Jul |
Date Detail:
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Created Date: 2000-08-01 Completed Date: 2000-08-01 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0404243 Medline TA: J Nutr Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1831-3 Citation Subset: IM |
Affiliation:
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Laboratory of Medicinal Chemistry and Radiopharmacy, Université Catholique de Louvain, B-1200 Brussels, Belgium. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Animals Electron Spin Resonance Spectroscopy* Free Radicals / analysis Glycyrrhiza / chemistry* Male Mice Plants, Medicinal* |
| Chemical | |
Reg. No./Substance:
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0/Free Radicals |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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