Document Detail


Free radical scavenging properties of apomorphine enantiomers and dopamine: possible implication in their mechanism of action in parkinsonism.
MedLine Citation:
PMID:  9620059     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The influence of R(-) apomorphine, S(+) apomorphine and dopamine on the oxidation kinetics of two polyunsaturated fatty acids (PUFA) (cholesteryl linoleate (CL) and Trilinolein (TL)) was investigated. The oxidation was initiated by free radicals generated through thermal decomposition of 2.2'-Azobis(2-methyl-propionitrile) (AMPN) in phosphate buffer (pH 7.4) thermostated at 50 degrees C. The hydroperoxides formed were determined by iodine titration using a diode array spectrophotometer at 290nm. Both enantiomers of apomorphine as well as dopamine exerted an inhibitory effect. Tocopherol (alpha-tocopherol) and ascorbic acid were used as controls. The former inhibited while ascorbic acid facilitated the oxidation reaction. These results are discussed in relation with the possible role of oxidative injury in parkinsonism and the usefulness of apomorphine in elevating "on-off" episodes. On this basis, the non-dopaminergic enantiomer of apomorphine (S(+)-isomer) is put foward to test the importance of its radical scavenging properties in parkinsonism which could eventually lead to a therapeutic alternative with less side effects.
Authors:
E E Sam; N Verbeke
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of neural transmission. Parkinson's disease and dementia section     Volume:  10     ISSN:  0936-3076     ISO Abbreviation:  J Neural Transm Park Dis Dement Sect     Publication Date:  1995  
Date Detail:
Created Date:  1998-06-17     Completed Date:  1998-06-17     Revised Date:  2000-12-18    
Medline Journal Info:
Nlm Unique ID:  8914371     Medline TA:  J Neural Transm Park Dis Dement Sect     Country:  AUSTRIA    
Other Details:
Languages:  eng     Pagination:  115-27     Citation Subset:  IM    
Affiliation:
Laboratorium voor Galenische en Klinische Farmacie, Leuven, Belgium.
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MeSH Terms
Descriptor/Qualifier:
Apomorphine / chemistry*
Ascorbic Acid
Corpus Striatum / chemistry*
Dopamine / chemistry*
Free Radicals
Oxidative Stress
Parkinson Disease / metabolism*
Peroxides / chemistry
Spectrophotometry
Chemical
Reg. No./Substance:
0/Free Radicals; 0/Peroxides; 50-81-7/Ascorbic Acid; 58-00-4/Apomorphine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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