Document Detail

Free radical scavenging activity and antiproliferative potential of Polygonum cuspidatum root extracts.
MedLine Citation:
PMID:  20082145     Owner:  NLM     Status:  MEDLINE    
Polygonum cuspidatum is widely used as a medicinal herb in Asia. In this study, ethanol and ethyl acetate extracts of P. cuspidatum root were assayed for their 1,1-diphenyl-2-hydrazyl (DPPH) and hydroxyl free radical scavenging activities, total phenolics content, protective effect against DNA damage, and antiproliferative activity on human lung cancer cells. The ethanol and ethyl acetate (lipophilic phase) extracts of P. cuspidatum had significant scavenging effects on DPPH and hydroxyl radicals. Total phenolics content of ethanol and ethyl acetate (lipophilic phase) extracts of P. cuspidatum were 276.78 +/- 39.31 and 231.73 +/- 5.04 mg/ml, respectively; both extracts protected against hydroxyl radical-induced DNA strand scission. Furthermore, the extracts of P. cuspidatum induced apoptosis and inhibited cell growth in A549 and H1650 cell lines, suggesting that P. cuspidatum root extracts exhibit an antiproliferative effect on human lung cancer cells.
Yun-Wei Lin; Fu-Jung Yang; Chia-Ling Chen; Wei-Ting Lee; Ruey-Shyang Chen
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of natural medicines     Volume:  64     ISSN:  1861-0293     ISO Abbreviation:  J Nat Med     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-03-24     Completed Date:  2010-10-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101518405     Medline TA:  J Nat Med     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  146-52     Citation Subset:  IM    
Department of Biochemical Science and Technology, National Chiayi University, 300 University Road, Chiayi, Taiwan, ROC.
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MeSH Terms
Cell Line, Tumor
Cell Proliferation / drug effects*
Dose-Response Relationship, Drug
Free Radical Scavengers / isolation & purification,  pharmacology*
Growth Inhibitors / isolation & purification,  pharmacology*
Plant Extracts / isolation & purification,  pharmacology*
Plant Roots*
Polygonum cuspidatum*
Tumor Cells, Cultured
Reg. No./Substance:
0/Free Radical Scavengers; 0/Growth Inhibitors; 0/Plant Extracts

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