| Free radical scanvenging and antioxidant effects of some anthraquinone derivatives. | |
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MedLine Citation:
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PMID: 22313303 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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In this study, the screening of five anthraquinones (purpurin, xanthopurpurin, rubiadin, kermisic acid and flavokermisic acid), for their free radical scavenging and antioxidant effects was carried out, using three complementary methods. DPPH (2,2'-diphenyl-1-picrylhydrazyl) revealed that purpurin has a scavenging effect with IC50 = 3.491 ± 0.014 µg/ml. Results of β-carotene / linoleic acid assay showed that kermisic and flavokermisic acids have significant inhibition of lipid peroxidation with I % = 76.1 ± 1.5 % and 68.6 ± 2.5 %, respectively. In addition, the ferrous ion chelating test showed that only purpurin, with small concentrations, interferes in a dose dependant manner with the formation of Fe2+- ferrozine complex. These results are promising for further studies of the biological and pathological effects of these natural products. |
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Authors:
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Abderrahmane Baghiani; Noureddine Charef; Meriem Djarmouni; Haythem A Saadeh; Lekhmici Arrar; Mohammad S Mubarak |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Medicinal chemistry (Shāriqah (United Arab Emirates)) Volume: 7 ISSN: 1875-6638 ISO Abbreviation: Med Chem Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2012-02-08 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101240303 Medline TA: Med Chem Country: Netherlands |
Other Details:
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Languages: eng Pagination: 639-44 Citation Subset: IM |
Affiliation:
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Prof Lekhmici Arrar, Laboratory f Applied Biochemistry, Department of Biochemistry, Faculty of Nature and Life Sciences, University Ferhat Abbas-Setif 19000, Algeria. mmubarak@ju.edu.jo. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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