Document Detail


Free radical reaction and biological defense mechanism in the pathogenesis of prolonged vasospasm in experimental subarachnoid hemorrhage.
MedLine Citation:
PMID:  3339099     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The relationship between free radical reactions and the defense mechanisms against them was investigated in the pathogenesis of prolonged vasospasm following experimental subarachnoid hemorrhage (SAH) in dogs. The concentration of lipid peroxides in the cerebro spinal fluid (CSF) increased markedly up to the eighth day following SAH; the concentrations also rose in the arterial wall (p less than 0.01) and the gray matter of the temporal lobe where the subarachnoid blood clots were (p less than 0.01). On the other hand, the activity of superoxide dismutase (SOD) decreased significantly up to the eighth day after SAH (p less than 0.01), and there was a gradual increase of glutathione peroxidase (GSH-px) in the CSF. In the arterial wall, there was a slight decrease in the activity of SOD, a significant decrease in the activity of GSH-px (p less than 0.01), and also a significant decrease in the concentration of glutathione (p less than 0.01) up to the eighth day following SAH. In conclusion, lipid peroxidation with insufficient biological defense mechanisms against it in the arterial wall, concomitant with that in the CSF, might take part in the genesis of prolonged vasospasm following SAH.
Authors:
S Sakaki; S Ohta; H Nakamura; S Takeda
Related Documents :
19624339 - Papilledema revisited: is its pathophysiology really understood?
15446589 - Chronic hydrocephalus in adults.
16740629 - An axisymmetric and fully 3d poroelastic model for the evolution of hydrocephalus.
1996449 - Hydrocephalus: overdrainage by ventricular shunts. a review and recommendations.
1030319 - Neurologic complications of gas myelography by the lumbar route.
8517189 - Cerebrospinal fluid circulation and associated intracranial dynamics. a radiologic inve...
14992899 - Lung perfusion with protective solution relieves lung injury in corrections of tetralog...
6831809 - Steroid-induced femoral head pressure changes and their response to lipid-clearing agents.
9249479 - In vivo adaptive responses of the aorta to hypertension and aging.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism     Volume:  8     ISSN:  0271-678X     ISO Abbreviation:  J. Cereb. Blood Flow Metab.     Publication Date:  1988 Feb 
Date Detail:
Created Date:  1988-03-07     Completed Date:  1988-03-07     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8112566     Medline TA:  J Cereb Blood Flow Metab     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1-8     Citation Subset:  IM    
Affiliation:
Department of Neurological Surgery, Ehime University School of Medicine, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Basilar Artery / pathology
Brain / metabolism
Cerebral Arteries / metabolism
Dogs
Free Radicals
Glutathione / metabolism
Glutathione Peroxidase / metabolism
Histocytochemistry
Lipid Peroxides / cerebrospinal fluid,  metabolism*
Parietal Lobe / metabolism
Pons / metabolism
Spasm
Subarachnoid Hemorrhage / complications*,  metabolism,  pathology
Superoxide Dismutase / metabolism
Temporal Lobe / metabolism
Vascular Diseases / etiology*
Chemical
Reg. No./Substance:
0/Free Radicals; 0/Lipid Peroxides; 70-18-8/Glutathione; EC 1.11.1.9/Glutathione Peroxidase; EC 1.15.1.1/Superoxide Dismutase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Regulation of acetylcholine receptor transcript expression during development in Xenopus laevis.
Next Document:  Autoradiographic determination of cerebral glucose content, blood flow, and glucose utilization in f...