| Free radical-dependent suppression of growth of mouse myeloma cells by alpha-linolenic and eicosapentaenoic acids in vitro. | |
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MedLine Citation:
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PMID: 7757958 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Alpha-linolenic acid (ALA) and eicosapentaenoic acid (EPA) exhibited potent cytotoxic action on SP 2/0 mouse myeloma cells in vitro. Both SOD and vitamin E could inhibit the action of ALA and EPA indicating a role for reactive oxygen species and lipid peroxides. In addition, both ALA and EPA enhanced the formation of superoxide anion, hydrogen peroxide and lipid peroxides, and caused a reduction in the levels of antioxidant enzymes: SOD, catalase and glutathione peroxidase and induced significant damage to DNA in SP 2/0 cells. Thus, ALA and EPA inhibit antioxidant defenses of the cell and damage the DNA, which can ultimately lead to tumor cell lysis. |
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Authors:
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G S Kumar; U N Das |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Cancer letters Volume: 92 ISSN: 0304-3835 ISO Abbreviation: Cancer Lett. Publication Date: 1995 May |
Date Detail:
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Created Date: 1995-06-27 Completed Date: 1995-06-27 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7600053 Medline TA: Cancer Lett Country: IRELAND |
Other Details:
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Languages: eng Pagination: 27-38 Citation Subset: IM |
Affiliation:
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Department of Medicine, Nizam's Institute of Medical Sciences, Punjagutta, Hyderabad, India. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Catalase / drug effects, metabolism Cell Division / drug effects Cell Survival / drug effects DNA Damage DNA, Neoplasm / drug effects* Eicosapentaenoic Acid / pharmacology* Free Radicals / metabolism* Glutathione Peroxidase / drug effects, metabolism Lipid Peroxidation / drug effects* Mice Multiple Myeloma / metabolism*, pathology* Superoxide Dismutase / drug effects, metabolism alpha-Linolenic Acid / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/DNA, Neoplasm; 0/Free Radicals; 1553-41-9/Eicosapentaenoic Acid; 463-40-1/alpha-Linolenic Acid; EC 1.11.1.6/Catalase; EC 1.11.1.9/Glutathione Peroxidase; EC 1.15.1.1/Superoxide Dismutase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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