Document Detail


Free radical-dependent suppression of growth of mouse myeloma cells by alpha-linolenic and eicosapentaenoic acids in vitro.
MedLine Citation:
PMID:  7757958     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Alpha-linolenic acid (ALA) and eicosapentaenoic acid (EPA) exhibited potent cytotoxic action on SP 2/0 mouse myeloma cells in vitro. Both SOD and vitamin E could inhibit the action of ALA and EPA indicating a role for reactive oxygen species and lipid peroxides. In addition, both ALA and EPA enhanced the formation of superoxide anion, hydrogen peroxide and lipid peroxides, and caused a reduction in the levels of antioxidant enzymes: SOD, catalase and glutathione peroxidase and induced significant damage to DNA in SP 2/0 cells. Thus, ALA and EPA inhibit antioxidant defenses of the cell and damage the DNA, which can ultimately lead to tumor cell lysis.
Authors:
G S Kumar; U N Das
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cancer letters     Volume:  92     ISSN:  0304-3835     ISO Abbreviation:  Cancer Lett.     Publication Date:  1995 May 
Date Detail:
Created Date:  1995-06-27     Completed Date:  1995-06-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7600053     Medline TA:  Cancer Lett     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  27-38     Citation Subset:  IM    
Affiliation:
Department of Medicine, Nizam's Institute of Medical Sciences, Punjagutta, Hyderabad, India.
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MeSH Terms
Descriptor/Qualifier:
Animals
Catalase / drug effects,  metabolism
Cell Division / drug effects
Cell Survival / drug effects
DNA Damage
DNA, Neoplasm / drug effects*
Eicosapentaenoic Acid / pharmacology*
Free Radicals / metabolism*
Glutathione Peroxidase / drug effects,  metabolism
Lipid Peroxidation / drug effects*
Mice
Multiple Myeloma / metabolism*,  pathology*
Superoxide Dismutase / drug effects,  metabolism
alpha-Linolenic Acid / pharmacology*
Chemical
Reg. No./Substance:
0/DNA, Neoplasm; 0/Free Radicals; 1553-41-9/Eicosapentaenoic Acid; 463-40-1/alpha-Linolenic Acid; EC 1.11.1.6/Catalase; EC 1.11.1.9/Glutathione Peroxidase; EC 1.15.1.1/Superoxide Dismutase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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