Document Detail

Free radical and antioxidant levels in patients with secondary peritonitis and their prognostic significance.
MedLine Citation:
PMID:  17664875     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The clinical outcome of patients with secondary bacterial peritonitis depends on the production of superoxides involved in bacterial killing and the endogenous level of antioxidants. The prognostic significance of their levels has not previously been investigated. PATIENTS AND METHODS: Forty-five patients undergoing surgery for secondary peritonitis were prospectively evaluated. Severity of illness at admission (APACHE II score) was correlated with admission levels of superoxide radicals and antioxidants (superoxide dismutase (SOD), catalase and glutathione peroxidase). Levels were compared with general surgery controls (n = 10). Superoxide and antioxidant levels at admission (day 1) and post-operative days 3 and 5/7 were then correlated with outcome. RESULTS: Nine of the 45 patients died (20% mortality) and 17 patients had complications (47% morbidity). The mean APACHE II score on admission was significantly higher among non-survivors than survivors (p < 0.01). The APACHE II score on admission correlated with the level of free radicals (r = 0.477, p < 0.01), catalase (r = -0.489, p < 0.01) and SOD (r = -0.357, p < 0.05). Admission superoxide levels were higher and antioxidant levels lower in peritonitis patients than controls. Levels did not significantly change following surgical intervention and post-operative levels did not correlate with outcome. CONCLUSION: The levels of superoxide and antioxidants correlate with the severity of illness on admission in patients with secondary peritonitis, but serial levels following surgical intervention do not predict outcome.
Yogesh Kumar; Gurpreet Singh; Brian R Davidson
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Publication Detail:
Type:  Journal Article     Date:  2007-07-27
Journal Detail:
Title:  Digestive surgery     Volume:  24     ISSN:  0253-4886     ISO Abbreviation:  Dig Surg     Publication Date:  2007  
Date Detail:
Created Date:  2007-10-03     Completed Date:  2008-01-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8501808     Medline TA:  Dig Surg     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  331-7     Citation Subset:  IM    
University Department of Surgery, Royal Free Hospital, Royal Free and University College Medical School, UCL, London, UK.
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MeSH Terms
Aged, 80 and over
Analysis of Variance
Biological Markers / blood
Catalase / blood*
Critical Illness
Glutathione Peroxidase / blood
Middle Aged
Outcome Assessment (Health Care)
Peritonitis / diagnosis*,  mortality
Prospective Studies
Superoxide Dismutase / blood*
Superoxides / blood*
Survival Rate
Reg. No./Substance:
0/Biological Markers; 11062-77-4/Superoxides; EC; EC Peroxidase; EC Dismutase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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