Document Detail


Free protein S deficiency in hemodialysis patients due to vascular calcifications?
MedLine Citation:
PMID:  8893155     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Vascular calcifications are frequent in hemodialysis patients. Its incidence ranges from 25 to 67% depending of different series. Thirty hemodialysis patients were selected from a dialysis population of 150 patients. These 30 patients were divided into two groups: group I included 15 hemodialysis patients with severe secondary hyperparathyroidism and severe, roentgenographically visible diffuse vascular calcifications, and group II included 15 other hemodialysis patients with moderate hyperparathyroidism without radiographic evidence of arterial calcifications. The control group comprised 20 normal volunteers. In all patients, measurements of protein C activity, free protein S and intact parathyroid hormone (PTH) were performed. Statistical analysis showed that free protein S in the patients of group I had a tendency to be lower than in the patients of group II (p < 0.01) and the control group (p < 0.001). We did not find significant differences in free protein S between group II and control group patients nor a significant correlation between intact PTH and free protein S in groups I and II. Protein C activity was found to be in the normal range in both groups. Free protein S deficiency in patients of group I would suggest a synthesis defect by impaired endothelial cells-due to vascular calcifications (?). Free protein S deficiency could increase the risk of thrombotic complications in these patients.
Authors:
R Perez-Mijares; J Payan-Lopez; J L Guzman-Zamudio; J I Sanchez-Angulo; P Gomez-Fernandez; M Ramos-Diaz; M Alcala-Rueda; G Silgado-Rodriguez; L Hermosin-Ramos; M Almaraz-Jimenez
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nephron     Volume:  74     ISSN:  0028-2766     ISO Abbreviation:  Nephron     Publication Date:  1996  
Date Detail:
Created Date:  1997-02-13     Completed Date:  1997-02-13     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0331777     Medline TA:  Nephron     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  356-60     Citation Subset:  IM    
Affiliation:
Nephrology Service, General Hospital, Jerez, Spain.
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MeSH Terms
Descriptor/Qualifier:
Adult
Calcinosis / blood*,  etiology
Erythropoietin / therapeutic use
Female
Humans
Male
Middle Aged
Parathyroid Hormone / blood
Protein C / analysis
Protein S / metabolism*
Protein S Deficiency / blood,  etiology*
Recombinant Proteins / therapeutic use
Reference Values
Renal Dialysis / adverse effects*
Vascular Diseases / blood*,  etiology
Chemical
Reg. No./Substance:
0/Parathyroid Hormone; 0/Protein C; 0/Protein S; 0/Recombinant Proteins; 11096-26-7/Erythropoietin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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