Document Detail


Free light chain monomers in the diagnosis of multiple sclerosis.
MedLine Citation:
PMID:  20870296     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A new procedure of free light chain (FLC) analysis was developed to assist the diagnosis of multiple sclerosis (MS). In this procedure, Western blotting technique was used to analyze monomeric and dimeric FLCs in the cerebrospinal fluid (CSF) and serum of patients with MS and other neurological diseases. The intensity of immunoreactive FLC bands was quantified by a specially developed software. Analysis of the obtained monomer/dimer patterns of κ and λ type FLCs allowed the determination of the diagnostically useful FLC parameters. The combined use of three FLC indices accounting for monomeric FLC-κ level and κ/λ ratio values in the CSF and serum was found to be of promising diagnostic importance for differentiation of MS from other non-MS neurological diseases.
Authors:
Batia Kaplan; Boris M Aizenbud; Sizilia Golderman; Regina Yaskariev; Ben-Ami Sela
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Publication Detail:
Type:  Journal Article     Date:  2010-09-25
Journal Detail:
Title:  Journal of neuroimmunology     Volume:  229     ISSN:  1872-8421     ISO Abbreviation:  J. Neuroimmunol.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-24     Completed Date:  2010-12-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8109498     Medline TA:  J Neuroimmunol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  263-71     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier B.V. All rights reserved.
Affiliation:
Heller Institute of Medical Research, Sheba Medical Center, Tel-Hashomer, Israel. address: batiakaplan@gmail.com
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MeSH Terms
Descriptor/Qualifier:
Female
Humans
Immunoglobulin Light Chains / blood*,  cerebrospinal fluid*
Male
Multiple Sclerosis* / blood,  cerebrospinal fluid,  diagnosis
Oligoclonal Bands / blood,  cerebrospinal fluid
Statistics, Nonparametric
Chemical
Reg. No./Substance:
0/Immunoglobulin Light Chains; 0/Oligoclonal Bands

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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