Document Detail

Free-knot spline model for analysis of pulmonary function.
MedLine Citation:
PMID:  19964292     Owner:  NLM     Status:  MEDLINE    
The pulmonary function test (PFT) is used to evaluate and monitor respiratory function. The PFT is critical for the care of patients having cystic fibrosis (CF) and adjusting their clinical treatments. We analyzed the percent predicted value of forced expiratory volume in one second (FEV(1)%) from PFT of CF patients collected four times a year from 1966. Longitudinal FEV(1)% for each patient was fitted with linear free-knot spline (FKS) model. We explained as the time when the PFT trend changes. We classified the patients' pulmonary function trend using eight groups of FEV(1)% based on the angle of linear FKS model. The overlapped majority of knots in groups located at 1978, 1991, and 1993 for worsening and at 1983, 1988, and 2000 for not worsening.
Yong W Lee; Jongwon Lee; Wha J Yoo; Hyeong S Yoo; Warren J Warwick
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference     Volume:  2009     ISSN:  1557-170X     ISO Abbreviation:  Conf Proc IEEE Eng Med Biol Soc     Publication Date:  2009  
Date Detail:
Created Date:  2009-12-07     Completed Date:  2010-03-16     Revised Date:  2014-08-21    
Medline Journal Info:
Nlm Unique ID:  101243413     Medline TA:  Conf Proc IEEE Eng Med Biol Soc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3255-8     Citation Subset:  IM    
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MeSH Terms
Cystic Fibrosis / physiopathology*
Data Interpretation, Statistical
Databases, Factual
Forced Expiratory Volume*
Lung / physiology*
Middle Aged
Respiratory Function Tests
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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