Document Detail

Free flap failure secondary to dual thrombophilia.
MedLine Citation:
PMID:  18833574     Owner:  NLM     Status:  MEDLINE    
Much has been learned over the past several decades regarding thrombophilic conditions. Thrombotic complications, such as deep venous thrombosis, pulmonary embolus, myocardial infarction, and stroke, are sometimes attributed to a diagnosable thrombophilia. Less has been written with regard to their effect on reconstructive outcomes. Fortunately, it is rare to encounter a notable intraoperative thrombophilia while performing reconstructive microsurgery. When this does occur, salvage can be difficult and outcome can be compromised. It is imperative that microsurgeons be knowledgeable of both major and minor thrombogenic conditions to optimize intraoperative outcome and postoperative care. We present a case of a failed free flap for lower extremity reconstruction associated with hyperhomocysteinemia in conjunction with markedly elevated Factor VIII levels.
Michael Robert Davis; Daniel Huff Shell; Marisa Marques; James Neal Long
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Microsurgery     Volume:  29     ISSN:  1098-2752     ISO Abbreviation:  Microsurgery     Publication Date:  2009  
Date Detail:
Created Date:  2009-01-14     Completed Date:  2009-04-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8309230     Medline TA:  Microsurgery     Country:  United States    
Other Details:
Languages:  eng     Pagination:  62-5     Citation Subset:  IM    
Division of Plastic Surgery, University of Alabama at Birmingham, School of Medicine, Birmingham, AL 35294-3411, USA.
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MeSH Terms
Factor VIII
Graft Survival
Homocysteine / blood
Hyperhomocysteinemia / complications
Leg / surgery
Microsurgery / adverse effects*
Middle Aged
Postoperative Complications
Reconstructive Surgical Procedures / adverse effects*
Surgical Flaps / adverse effects*
Thrombophilia / complications*
Thrombosis / blood,  etiology*,  ultrasonography
Ultrasonography, Doppler
Reg. No./Substance:
454-28-4/Homocysteine; 9001-27-8/Factor VIII

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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