Document Detail

Free ferulic acid uptake in ram lambs.
MedLine Citation:
PMID:  22205674     Owner:  NLM     Status:  Publisher    
The objective of this research was to investigate the fate of free ferulic acid (FA) in sheep. Ferulic acid is normally present in plants, bound to the indigestible cell wall. If the FA present in a ruminant diet is released from the cell wall with feed pretreatment methods, FA may be released into the rumen for digestion and/or absorption into the bloodstream. Eight male Dorset x Finn lambs were randomly assigned to 1 of 4 treatment (trt) concentrations, 0 (control), 3, 6 or 9 g/d free FA as part of a replicated 4 x 4 Latin square design. Lambs were housed individually and consumed chopped alfalfa hay (Medicago sativa) (22.8% CP, 39.3% NDF, 0.73 Mcal/kg NE(g)) ad libitum and 350 g corn grain (Zea mays L.) (9.1% CP, 11.2% NDF, 1.52 Mcal/kg NE(g)) once daily at 0800 h. Basal levels of FA in hay, grain, blood, feces and urine were established following a 14 d adjustment to diet and housing. An oral dose of free FA was administered for 5 d via bolus after each morning feeding, after which hay, grain, blood, feces and urine were sampled. Body weights were recorded at the beginning and end of each trt, and DMI was measured daily during trt periods. In addition to trt, each lamb ingested a daily average of 3.78 g FA in its bound form via the offered hay (2.67 mg/g FA; 1.0 kg/d DMI) and corn (3.17 mg/g FA; 0.35 kg/d DMI). The FA administered had a quadratic effect on average hay DMI (1.25, 1.41, 1.41 and 1.29 kg/d for 0, 3, 6 or 9 g/d FA trt; P < 0.01; SE = 58.9 g), but lamb BW did not change as a result of FA trt (P = 0.28). The NDF level and amount of FA in refusals were not affected by trt, (P = 0.30; P = 0.82, respectively). Fecal FA did not differ among trt or when compared to basal FA (P = 0.53) while urine FA increased as FA dose increased (P < 0.01), indicating that free FA was absorbed and transferred into urine. No free FA was found in the plasma analyzed, suggesting that disappearance from the blood of absorbed free FA occurred within the 5 h that passed between bolus dosage and blood collection. An in vitro analysis was conducted to assess the degree of inhibition of microbial NDF digestion caused by FA supplementation. In vitro NDF disappearance was not inhibited as a result of FA treatment (P = 0.80). These data in combination with the results of the lamb study indicate that free FA as 0.24, 0.43 and 0.70 percent of DMI in lambs is absorbed and excreted in the urine as opposed to the feces with no apparent effects on rumen microbial NDF digestion.
M A Soberon; D J R Cherney; J H Cherney
Related Documents :
16663034 - Hemicellulosic polymers of cell walls of zea coleoptiles.
8183994 - Neoplastic transformation of c3h 10t1/2 cells: a study with fractionated doses of monoe...
17336914 - Detection of early hydroxychloroquine retinal toxicity enhanced by ring ratio analysis ...
16751064 - Vegf-associated tyrosine kinase inhibition increases the tumor response to single and f...
6510394 - Sensitivity of nestling and adult starlings to dicrotophos, an organophosphate pesticide.
15885254 - Concurrent measures of feeding and locomotion in rats.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-12-28
Journal Detail:
Title:  Journal of animal science     Volume:  -     ISSN:  1525-3163     ISO Abbreviation:  -     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8003002     Medline TA:  J Anim Sci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Cornell University, Ithaca, NY 14850.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  9-cis retinoic acid inhibits cumulus cell apoptosis during the maturation of bovine cumulus-oocyte-c...
Next Document:  The Kurtzke EDSS rank stability increases 4 years after the onset of multiple sclerosis: results fro...