Document Detail

Free fatty acids repress small heterodimer partner (SHP) activation and adiponectin counteracts bile acid-induced liver injury in superobese patients with nonalcoholic steatohepatitis.
MedLine Citation:
PMID:  23299969     Owner:  NLM     Status:  MEDLINE    
CONCLUSION: BA synthesis and serum BA levels correlated with disease severity in NAFLD, while adiponectin is reversely correlated. FFA exposure prevented SHP-mediated repression of NTCP and Cyp7A1 expression, which lead to increased BA synthesis and uptake. In NASH, BA accumulation induced hepatocyte cell death and late FXR activation failed to prevent hepatocyte injury due to decreased adiponectin levels. Early treatment with FXR ligands and/or adiponectin-receptor agonists might prevent NASH.
Lars P Bechmann; Peri Kocabayoglu; Jan-Peter Sowa; Svenja Sydor; Jan Best; Martin Schlattjan; Anja Beilfuss; Johannes Schmitt; Rebekka A Hannivoort; Alpaslan Kilicarslan; Christian Rust; Frieder Berr; Oliver Tschopp; Guido Gerken; Scott L Friedman; Andreas Geier; Ali Canbay
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Hepatology (Baltimore, Md.)     Volume:  57     ISSN:  1527-3350     ISO Abbreviation:  Hepatology     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-04-09     Completed Date:  2013-07-05     Revised Date:  2013-08-23    
Medline Journal Info:
Nlm Unique ID:  8302946     Medline TA:  Hepatology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1394-406     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 American Association for the Study of Liver Diseases.
Department of Gastroenterology and Hepatology, University Hospital, University Duisburg-Essen, Essen, Germany.
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MeSH Terms
Adiponectin / blood,  physiology*
Antigens, CD95 / metabolism
Bile Acids and Salts / adverse effects*,  blood,  physiology
Cholesterol 7-alpha-Hydroxylase / metabolism
Disease Progression
Fatty Acids, Nonesterified / blood,  physiology*
Fatty Liver / blood,  epidemiology,  physiopathology*
Liver / injuries*,  metabolism,  physiopathology
Middle Aged
Obesity / blood,  epidemiology,  physiopathology
Obesity, Morbid / blood,  epidemiology,  physiopathology*
Organic Anion Transporters, Sodium-Dependent / metabolism
Receptors, Cytoplasmic and Nuclear / blood,  metabolism,  physiology*
Severity of Illness Index
Symporters / metabolism
Reg. No./Substance:
0/Adiponectin; 0/Antigens, CD95; 0/Bile Acids and Salts; 0/Fatty Acids, Nonesterified; 0/Organic Anion Transporters, Sodium-Dependent; 0/Receptors, Cytoplasmic and Nuclear; 0/Symporters; 0/farnesoid X-activated receptor; 0/nuclear receptor subfamily 0, group B, member 2; 145420-23-1/sodium-bile acid cotransporter; EC protein, human; EC 7-alpha-Hydroxylase
Comment In:
Ann Hepatol. 2013 Jul-Aug;12(4):642-3   [PMID:  23813144 ]

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