Document Detail


Free fatty acids regulate the uncoupling protein and alternative oxidase activities in plant mitochondria.
MedLine Citation:
PMID:  9744802     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Two energy-dissipating systems, an alternative oxidase and an uncoupling protein, are known to exist in plant mitochondria. In tomato fruit mitochondria linoleic acid, a substrate for the uncoupling protein, inhibited the alternative oxidase-sustained respiration and decreased the ADP/O ratio to the same value regardless of the level of alternative oxidase activity. Experiments with varying concentrations of linoleic acid have shown that inhibition of the alternative oxidase is more sensitive to the linoleic acid concentration than the uncoupling protein activation. It can be proposed that these dissipating systems work sequentially during the life of the plant cell, since a high level of free fatty acid-induced uncoupling protein activity excludes alternative oxidase activity.
Authors:
F E Sluse; A M Almeida; W Jarmuszkiewicz; A E Vercesi
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  FEBS letters     Volume:  433     ISSN:  0014-5793     ISO Abbreviation:  FEBS Lett.     Publication Date:  1998 Aug 
Date Detail:
Created Date:  1998-10-08     Completed Date:  1998-10-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0155157     Medline TA:  FEBS Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  237-40     Citation Subset:  IM    
Affiliation:
Departamento de Patologia Clínica, Faculdade de Ciências Médicas, Universidade Estadual de Campinas, SP, Brazil.
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MeSH Terms
Descriptor/Qualifier:
Carrier Proteins / metabolism*
Dithiothreitol / pharmacology
Fatty Acids, Nonesterified / pharmacology*
Guanosine Triphosphate / pharmacology
Ion Channels
Kinetics
Linoleic Acid / pharmacology
Lycopersicon esculentum / metabolism*
Membrane Proteins / metabolism*
Mitochondria / drug effects,  metabolism*
Mitochondrial Proteins
Oxidoreductases / metabolism*
Oxygen Consumption / drug effects
Potassium Cyanide / pharmacology
Pyruvic Acid / metabolism
Chemical
Reg. No./Substance:
0/Carrier Proteins; 0/Fatty Acids, Nonesterified; 0/Ion Channels; 0/Membrane Proteins; 0/Mitochondrial Proteins; 0/mitochondrial uncoupling protein; 127-17-3/Pyruvic Acid; 151-50-8/Potassium Cyanide; 2197-37-7/Linoleic Acid; 3483-12-3/Dithiothreitol; 86-01-1/Guanosine Triphosphate; EC 1.-/Oxidoreductases; EC 1.-/alternative oxidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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