| Free fatty acids and the metabolic syndrome in patients with obstructive sleep apnoea. | |
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MedLine Citation:
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PMID: 21177837 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Obesity and metabolic syndrome (MS) occur frequently in patients with obstructive sleep apnoea (OSAS). We hypothesized that circulating free fatty acids (FFAs) are elevated in OSAS patients independently of obesity. This elevation may contribute to the development of the MS in these patients. We studied 119 OSAS patients and 119 controls. Participants were recruited and studied at sleep unit of our institution and were matched for gender, age and BMI. The occurrence of the MS was analysed by clinical criteria. Serum levels of FFAs, glucose, triglycerides, cholesterol, HDL cholesterol, aspartate-aminotransferase, alanine-aminotransferase, gamma-glutamyltransferase, C-reactive protein and 8-isoprostanes were determined. Prevalence of MS was higher in OSAS than in the control group (38 vs 21%, p=0.006). OSAS patients had higher FFAs levels than controls (12.2±4.9 vs 10.5±5.0mg·dL(-1), p=0.015). Among subjects without MS, OSAS patients (OSAS+MS-) showed higher levels of FFAs than controls (OSAS- MS-) (11.6±4.7 vs 10.0±4.4mg·dL(-1), p=0.04). In a multiple regression model, after adjustment for age, gender, BMI and the presence of metabolic syndrome, FFAs were significantly associated with AHI (p=0.04). This study shows that FFAs are elevated in OSAS and could be one of the mechanisms involved in the metabolic complications of OSAS. |
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Authors:
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A Barceló; J Piérola; M de la Peña; C Esquinas; A Fuster; M Sanchez; M Carrera; A Alonso-Fernandez; A Ladaria; M Bosch; F Barbé |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2010-12-23 |
Journal Detail:
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Title: The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology Volume: - ISSN: 1399-3003 ISO Abbreviation: - Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2011-1-5 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8803460 Medline TA: Eur Respir J Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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* Servei de Anàlisis Cliniques Hospital Universitari Son Dureta Palma de Mallorca Spain. |
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