Document Detail

Free fatty acids in human cerebrospinal fluid following subarachnoid hemorrhage and their potential role in vasospasm: a preliminary observation.
MedLine Citation:
PMID:  12186453     Owner:  NLM     Status:  MEDLINE    
OBJECT: The mechanisms leading to vasospasm following subarachnoid hemorrhage (SAH) remain unclear. Accumulation in cerebrospinal fluid (CSF) of free fatty acids (FFAs) may play a role in the development of vasospasm; however, in no previous study have concentrations of FFAs in CSF been examined after SAH. METHODS: We collected samples of CSF from 20 patients with SAH (18 cases of aneurysmal SAH and two cases of spontaneous cryptogenic SAH) and used a high-performance liquid chromatography assay to determine the FFA concentrations in these samples. We then compared these findings with FFA concentrations in the CSF of control patients. All FFA concentrations measured 24 hours after SAH were significantly greater than control concentrations (p < 0.01 for palmitic acid and < 0.001 for all other FFAs). All measured FFAs remained elevated for the first 48 hours after SAH (p < 0.05 for linoleic acid, p < 0.01 for palmitic acid, and p < 0.001 for the other FFAs). After 7 days, a second elevation in all FFAs was observed (p < 0.05 for linoleic acid, p < 0.01 for palmitic acid, and p < 0.001 for the other FFAs). Samples of CSF collected within 48 hours after SAH from patients in whom angiography and clinical examination confirmed the development of vasospasm after SAH were found to have significantly higher concentrations of arachidonic, linoleic, and palmitic acids than samples collected from patients in whom vasospasm did not develop (p < 0.05). CONCLUSIONS: Following SAH, all FFAs are initially elevated. A secondary elevation occurs between 8 and 10 days after SAH. This study provides preliminary evidence of FFA elevation following SAH and of a potential role for FFAs in SAH-induced vasospasm. A prospective study is warranted to determine if CSF concentrations of FFAs are predictive of vasospasm.
Julie G Pilitsis; William M Coplin; Michael H O'Regan; Jody M Wellwood; Fernando G Diaz; Marilynn R Fairfax; Daniel B Michael; John W Phillis
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of neurosurgery     Volume:  97     ISSN:  0022-3085     ISO Abbreviation:  J. Neurosurg.     Publication Date:  2002 Aug 
Date Detail:
Created Date:  2002-08-20     Completed Date:  2002-09-04     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0253357     Medline TA:  J Neurosurg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  272-9     Citation Subset:  AIM; IM    
Department of Neurosurgery, Wayne State University Detroit, Michigan 48201, USA.
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MeSH Terms
Aged, 80 and over
Arachidonic Acid / cerebrospinal fluid
Docosahexaenoic Acids / cerebrospinal fluid
Fatty Acids, Nonesterified / cerebrospinal fluid*,  physiology*
Linoleic Acid / cerebrospinal fluid
Middle Aged
Myristic Acid / cerebrospinal fluid
Oleic Acids / cerebrospinal fluid
Palmitic Acids / cerebrospinal fluid
Subarachnoid Hemorrhage / cerebrospinal fluid*,  complications,  physiopathology*
Time Factors
Vasospasm, Intracranial / cerebrospinal fluid*,  etiology,  physiopathology*
Reg. No./Substance:
0/Fatty Acids, Nonesterified; 0/Oleic Acids; 0/Palmitic Acids; 2197-37-7/Linoleic Acid; 25167-62-8/Docosahexaenoic Acids; 506-32-1/Arachidonic Acid; 544-63-8/Myristic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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