| Free fatty acid receptor 2 and nutrient sensing: a proposed role for fibre, fermentable carbohydrates and short-chain fatty acids in appetite regulation. | |
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MedLine Citation:
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PMID: 20482937 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The way in which the composition of the diet may affect appetite, food intake and body weight is now receiving considerable attention in a bid to halt the global year-on-year rise in obesity prevalence. Epidemiological evidence suggests that populations who follow a fibre-rich, traditional diet are likely to have a lower body weight and improved metabolic parameters than their Western-diet counterparts. The colonic effects of fibre, and more specifically the SCFA that the fermentation process produces, may play a role in maintaining energy homeostasis via their action on the G-coupled protein receptor free fatty acid receptor 2 (FFA2; formerly GPR43). In the present review, we summarise the evidence for and against the role of FFA2 in energy homeostasis circuits and the possible ways that these could be exploited therapeutically. We also propose that the decline in fibre content of the diet since the Industrial Revolution, particularly fermentable fractions, may have resulted in the FFA2-mediated circuits being under-utilised and hence play a role in the current obesity epidemic. |
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Authors:
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Michelle L Sleeth; Emily L Thompson; Heather E Ford; Sagen E K Zac-Varghese; Gary Frost |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review Date: 2010-05-19 |
Journal Detail:
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Title: Nutrition research reviews Volume: 23 ISSN: 1475-2700 ISO Abbreviation: Nutr Res Rev Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-07-01 Completed Date: 2010-09-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9113797 Medline TA: Nutr Res Rev Country: England |
Other Details:
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Languages: eng Pagination: 135-45 Citation Subset: IM |
Affiliation:
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Department of Investigative Medicine, Imperial College London, London, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Appetite Regulation
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physiology* Body Weight Diet* Dietary Carbohydrates* / administration & dosage Dietary Fiber* / administration & dosage Energy Metabolism Fatty Acids, Volatile* / administration & dosage Fermentation Homeostasis Humans Metabolic Syndrome X / prevention & control Obesity / epidemiology, prevention & control Receptors, Cell Surface / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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072643/Z/03/Z//Wellcome Trust; G7811974//Medical Research Council |
| Chemical | |
Reg. No./Substance:
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0/Dietary Carbohydrates; 0/Fatty Acids, Volatile; 0/G-protein coupled receptor 43, human; 0/Receptors, Cell Surface |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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