Document Detail

Free fatty acid metabolism of leg muscles during exercise in patients with obliterative iliac and femoral artery disease before and after reconstructive surgery.
MedLine Citation:
PMID:  4640949     Owner:  NLM     Status:  MEDLINE    
The free fatty acid (FFA) uptake and oxidation and the carbohydrate substrate exchange of leg muscles were studied during exercise in 14 patients with occlusive disease of the iliac or femoral arteries before and 3-6 months after reconstructive vascular surgery and in 5 healthy subjects. (14)C-labeled oleic acid was infused continuously at rest and during exercise at work loads of 150-400 kg-m/min. The arterial concentration of FFA was similar both at rest and during exercise in patients and controls. The patients showed a smaller increase in the fractional turnover of FFA during exercise. Leg uptake and release of FFA in terms of micromoles per liter plasma did not differ significantly either at rest or during exercise between patients and controls. FFA oxidation could not be measured at rest but exercise data showed a lower fractional oxidation of FFA (P < 0.001) in the patient group (53+/-6%) compared with the controls (84+/-2%). For the entire material, fractional oxidation of FFA showed a significant negative regression on the lactate/pyruvate ratio in femoral venous blood. The ventilatory respiratory quotient (RQ) and the leg muscle exchange of glucose and lactate in the patients exceeded that of the controls. When six patients were studied after reconstructive surgery, fractional oxidation of FFA had risen from a preoperative value of 47+/-8 to 90+/-10%, other data for leg muscle FFA metabolism being unchanged. IT IS CONCLUDED: (a) that substrate catabolism by the leg muscles during exercise in these patients proceeds in excess of the simultaneous capacity to oxidize acetyl-CoA in the tricarboxylic acid cycle, and (b) oxidation of FFA by contracting muscle is related to the muscle cell redox state.
L Hagenfeldt; J Wahren; B Pernow; R Cronestrand; S Ekeström
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of clinical investigation     Volume:  51     ISSN:  0021-9738     ISO Abbreviation:  J. Clin. Invest.     Publication Date:  1972 Dec 
Date Detail:
Created Date:  1973-02-15     Completed Date:  1973-02-15     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7802877     Medline TA:  J Clin Invest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  3061-71     Citation Subset:  AIM; IM; S    
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MeSH Terms
Arterial Occlusive Diseases / metabolism*,  surgery
Carbon Dioxide / biosynthesis
Carbon Isotopes
Chromatography, Gas
Fatty Acids, Nonesterified / blood,  metabolism*
Femoral Artery*
Glucose / metabolism
Iliac Artery*
Lactates / metabolism
Middle Aged
Muscles / metabolism*
Oleic Acids / metabolism
Oxygen Consumption
Physical Exertion*
Reg. No./Substance:
0/Carbon Isotopes; 0/Fatty Acids, Nonesterified; 0/Lactates; 0/Oleic Acids; 124-38-9/Carbon Dioxide; 50-99-7/Glucose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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